1D, Supplementary Dataset 2) when compared to the control cells. Hierarchical clustering of the top 50 (Fig. 1E) and 100 (Supplementary Fig. 1D) most changed genes following 4 h of LPS treatment showcased a module of upregulated genes, including many genes involved in the immune response...
Those proteins participate in the protein processing module in the ER, which includes components of the ER-associated degradation (ERAD) and components of the unfolded protein response (UPR). In addition to ribosomes and protein processing, we observed a down-regulation of proteins involved in ...
Box plot graphs show the module eigengenes of the purple k and turquoise m modules. One-way ANOVA with Tukey’s multiple comparisons test was used for statistical analysis in b, d, k, and m. Student’s t-test was used for statistical analysis in e. Error bars represent mean ± ...
tacrolimus and antibiotics together, and no treatment control. Y axis represents the ratios normalized level between the indicated metabolites. The ROC curve used to calculate area under curve (AUC) as a metric quantifying the overall ability of the metabolite to correctly classify the experimental co...
(Supplemental Table2A). KEGG BRITE hierarchy remains the benchmark for function classification, enabling the allocation of a metabolite to its respective KEGG compound, functional module, involved pathways, and functional class. According to the KEGG BRITE hierarchical classification system, 84 luminal ...
Our previously published reverse tetracycline- controlled transactivator (rtTA) module and the polycistronic OSK cistron under the control of a tetracycline-inducible promoter (Tet-on OSK) were transduced using lentivirus to create stable cell lines from the human fibroblasts and passaged until they ...
Structural similarity was computed based on Tanimoto score that was calculated from the Structure Clustering module of PubChem Compound database. A Tanimoto score was set to 0.7 for cut-off value for metabolite pair with structural similarity. In addition, connection of metabolite pair coupling by ...
the PCM loses communication with other modules on the vehicle that may set a number of "false" trouble codes for the transmission module, ABS module, body control module, etc. This does not indicate a problem and the codes can be erased after the flash reprogramming procedure has been complet...
(rtTA) module and the polycistronic OSK cistron under the control of a tetracycline-inducible promoter (Tet-on OSK) were transduced using lentivirus to create stable cell lines from the human fibroblasts and passaged until they reached replicative senescence. Treatment with doxycycline was sufficient...
clusters (modules) of highly related genes. Using the WGCNA algorithm (WGCNA R package) screen the miRNAs related to the osteogenic differentiation of BMSCs-exo. The optimal soft threshold was selected, and according to the correlation degree between each module and clinical pattern, the module ...