Ford 2 , Guangyong Peng 1,6 *The functional state of T cells is a key determinant for effective antitumor immunity and immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell differentiation, survival, and effector functions. Here, we report that development of T cell ...
Compared to normal macrophages, the activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key enzyme in glycolysis, is significantly lower in TAMs, even when substrates are abundant. This metabolic reprogramming gives way to tumor development [79]. Enhanced glycolysis in tumor cells increases...
https://github.com/jakka351/Barra-in-a-Beamer https://github.com/rollsch/j2534-logger https://github.com/kompumaster/E38-KEYFCKR https://github.com/wfahnestock/ME7-Suite https://github.com/chipsoft/canscaner https://github.com/fenugrec/freediag https://github.com/BrianHumlicek/J25...
DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target ge
Key determinants of short-term and long-term glioblastoma survival: a 14-year retrospective study of patients from the Hermelin Brain Tumor Center at Henry Ford Hospital. Clin Neurol Neurosurg. 2014;120:103–12. https://doi.org/10.1016/j.clineuro.2014.03.001. Article PubMed Google Scholar ...
(NFAT) is a key transcription factor regulating T-cell activation [340]. It increases the expression of multiple inhibitory receptors, including PD1, LAG3, TIM-3, and GITR, on the cell surface. Knocking out NFAT using gene editing was shown to significantly inhibit the expression of these ...
It is caused by a recurrent somatic missense mutation c.295 T > C (p.Cys99Arg; p.C99R) targeting the center of the DNA-binding domain of Interferon Regulatory Factor 4 (IRF4), a key TF in immune cells. IRF4-C99R fundamentally alters IRF4 DNA-binding, with loss-of-binding ...
Originally identified as a key defensive mechanism against invading viruses and plasmids in prokaryotic genomes,19,20 CRISPR-Cas systems have since been adapted for RNA-programmable genome editing.21 The most common and best studied of the CRISPR-Cas systems are those that involve the large, multi...
TGF│activation of glycolysis is a key feature of the fibrotic phenotype induced by TGF〣1 in skin cells, whilst increased glutaminolysis is also evident in SSc fibroblasts.doi:10.1111/jcmm.16013John HendersonFaculty of Health and Life Sciences Northumbria University Newcastle Upon Tyne UKLaura Duffy...
Stem cells made by reprogramming patients' own cells might one day be used as therapies for a host of diseases, but scientists have feared that dangerous mutations within these cells might be caused by current reprogramming techniques. A sophisticated new analysis of stem cells' DNA finds that su...