While oncogenic fusions of FUS and transcription factor DNA-binding domains are associated with soft tissue sarcomas, dominant mutations in FUS can cause amyotrophic lateral sclerosis. FUS has also been implica
Ribonucleoprotein/viral transcription 13 67.2 Cell-cell adhesion 3 45.0 mRNA splicing 9 41.8 Nucleotide binding 10 30.3 Chaperone/UPR 3 22.1 Viral nucleocapsid 3 19.0 mRNA nuclear export 4 17.5 Nucleotide binding/ATP binding 5 17.3 Translation initiation factors 11 13.2 Proteasome/NF-κB MAPK signaling...
Thus, only if ancML undergoes splicing, reverse transcription and integration in the host cell genome the intron is removed and a functional Neo (G418 resistance) protein is expressed. This approach has been used previously to monitor the intracellular replica- tion of retrotransposons [51]. We ...
5a and c). However, SAMHD1 expression did not show difference at both transcription and translation levels between HCT116 p53+/+ and HCT116 p53−/− cells (Fig. 5b and c). Phosphorylation of SAMHD1 at Thr 592 results in the inactivation of its antiretroviral function, but there were ...
The integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation f
Altogether, our results play in favor of a possible model in which nucleolin is involved in the nucleocytoplasmic export of vRNPs during IAV infection, even if we cannot exclude concomitant impact on other steps of viral replication (e.g. viral transcription, viral mRNA translation) due to the...
(HVR1). The 5'UTR is a highly conserved region that is involved in viral replication and translation [5], while the HVR1 codes for the amino end of the envelope protein E2. E2 is involved in binding of HCV to host cells [24]. Replication of HCV involves converting the viral genomic ...
(data not shown), indicating that the diel expression pattern of these key translation genes was less affected by UV stress than by daytime, at least around the LDT period. Most of the genes that were differentially regulated in the UV20vs. HL18 but not in the HL20vs. HL18 comparisons ...
(data not shown), indicating that the diel expression pattern of these key translation genes was less affected by UV stress than by daytime, at least around the LDT period. Most of the genes that were differentially regulated in the UV20vs. HL18 but not in the HL20vs. HL18 comparisons ...
(Current Ed., B. Hames and S. Higgins, eds.); Transcription and Translation (Current Ed., B. Hames and S. Higgins, eds.); CRC Handbook of Parvoviruses (P. Tijessen, ed.); Fundamental Virology, 2d Edition (B. N. Fields and D. M. Knipe, eds.); Current Protocols in Human ...