Replacing testosterone in menBMJ Publishing Group LtdReplacing testosterone in men. Drug Ther Bull 1999; 37: 3 ± 6.
5-alpha reductase is an enzyme associated with the nuclear membrane and it is found in high concentrations in the human male reproductive tissues, skin and liver. 5-alpha reductase catalyses the conversion of testosterone to dihydrotestosterone (DHT). Two isoenzymes (type I and II) of 5-alpha...
Around 1 in 200 men have abnormally low levels of circulating testosterone that result in hypogonadism.1 Most of these men should be offered testosterone replacement therapy. Here we outline the rationale for such treatment and the different preparations available. We do not discuss the use of ...