In cynomolgus monkeys, no effects on embryo-fetal or postnatal development (up to 6 months of age) were observed when evolocumab was dosed during organogenesis to parturition at 50 mg/kg once every 2 weeks by the subcutaneous route at exposures 30-and 12-fold the recommended human doses of ...
Measure low density lipoprotein cholesterol (LDL-C) levels every 4 to 8 weeks after start using the drug. If you miss a dose, use the missed dose within 7 days after the due injection time. Skip the missed dose if you pass more than 7 days for the injection. After missed a dose, re...
DOSAGE AND ADMINISTRATION • Administer by subcutaneous injection (2.1) See 17 for PATIENT COUNSELING INFORMATION and FDA- • Primary hyperlipidemia with established clinical atherosclerotic CVD or approved patient labeling. HeFH: 140 mg every 2 weeks or 420 mg once monthly in abdomen, thigh,...