ACE Inhibitor and Renin–Angiotensin System the Cornerstone of Therapy for Systolic Heart FailureHeart FailureACE-inhibitorsClinical trialHeart failure (HF) can be defined as an abnormality of cardiac structure or function leading to failure of the heart to deliver oxygen at a rate commensurate with ...
The significance of plasma renin levels in patients with dilated cardiomyopathy on therapeutic doses of ACE inhibitoreditorialsmyocardial infarctionrisk factorsprognosisAtherosclerosis/coronary artery disease (CAD) is largely a result of genetically linked dyslipidemias that can often be identified in clinical...
Is there a role for renin profiling in selecting chronic heart failure patients for ACE inhibitor treatment? Heart 2000;83(3):257–61.Lim P, MacFadyen R, Struthers A. Is there a role for renin profiling in selecting chronic heart failure patients for ACE inhibitor treatment? Heart 2000; 83...
31 Enalapril Innovace ACE inhibitor 16,340 32 Clavulanic acid Augmentin* Beta-lactamase inhibitor 16,285 33 Potassium chloride K-dur Potassium supplement 16,190 34 Norethindrone Loestrin* Steroid 161,31 35 Simvastatin Zocor HMG CoA reductase inhibitor 15,923 36 Metformin HCl Glucophage Hypoglycemic 15...
Nakata K, Nishimura K, Takada T, Ikuse T, Yamauchi H, Iso T (1987) Effects of an angiotensin-converting enzyme (ACE) inhibitor, SA 446, on tissue ACE activity in normotensive, spontaneously hypertensive, and renal hypertensive rats. J Cardiovasc Pharmacol 9: 305–310 ...
(chlorthalidone, amlodipine, lisinopril, or doxazosin) on the combined incidence of fatal coronary heart disease and nonfatal myocardial infarction. However, this trial had some major caveats related to poorer blood pressure control with the ACE inhibitor lisinopril in blacks that may have greatly ...
In addition to generating Ang II, ACE separately catalyzes the degradation of bradykinin. Therapeutic treatment with ACE inhibitor (ACEI) drugs, therefore, results in accumulation of bradykinin and suppression of Ang II.9 Bradykinin has been suggested to in part oppose the vascular and tissue ...
In addition to the effect of renin, the effects of AA infusion on the amount of aldosterone, angiotensin-II and ACE activity have also been measured. In these animal studies, renal blood flow, blood pressure, the amount of urine formed and the composition of urine (such as its sodium, ...
The renin acts on a circulating protein, angiotensinogen, to cleave out a fragment called angiotensin I (AI). AI itself has only slight pharamacologic activity but, after additional cleavage by a second enzyme, angiotensin converting enzyme (ACE), forms the potent molecule angiotensin II (AII)....
the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmac...