The increase in the life expectancy of patients with renal cell carcinoma (RCC) in the last decade is due to changes that have occurred in the area of preclinical studies. Understanding cancer pathophysiology and the emergence of new therapeutic options, including immunotherapy, would not be possibl...
Furthermore, fixed-dose combinations cannot be used in patients with creatinine clearance below 60 mL/min since the tablets available do not allow appropriate dosage adjustment for each drug. Chloroquine and proguanil require dosage adjustments, while atovaquone, doxycycline and mefloquine do not....
Two years before she had started sunitinib treatment because of a renal cancer pT3bN1M0. She was receiving an intermittent dosing, consisting of 4 weeks treatment followed by 2 weeks rest. The lesions spread during the administration of sunitinib and gradually improved after the completion of ...
Doxycycline Inhibiting metalloproteases and expression of CD 147 and has anti-inflammatory property Gastrointestinal side effects such as nausea, vomiting and abdominal pain [100], [101], [103] Baricitinib Janus kinase (JAK) inhibitor Upper respiratory tract infection, headache, nasopharyngitis, decreases...