Importantly, we revealed that the pathway of GO renal clearance depends on its lat- eral dimension, i.e., the small lateral sized s-GOs were excreted in urine by combination pathways of glomeru- lar filtration and tubular secretion, while the large lat- eral sized l-GOs was mainly through...
nanoparticlesrenalclearancetumoraciditytumortargetingThe success of nanomedicines in the clinic depends on our comprehensive understanding of nano–bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pHe) values. Herein, we ...
If the molecular weight of a toxin is low and protein binding is limited, dialyser clearance is expected to be high. This is a prerequisite for efficient removal. The body clearance depends on the compartmental behaviour. If the distribution is multicompartmental, with slow equilibration between ...
In addition, renal replacement therapy may be initiated for reasons other than clearance, for instance, to maintain a euvolemic fluid balance. Hence, AKI staging depends directly on the decision-making process rather than renal function.31 Finally, the timing of change is particularly important in ...
secreted by OCT2, competitively increase levels of creatinine without truly decreasing GFR.74However, other drugs are largely dependent on GFR for their elimination, as is the case for aminoglycoside andglycopeptideantibiotics; hence renal maturational changes will have great impact on their clearance. ...
As revealed by clinical studies, the kidneys consume up to 20% of the body’s total energy expenditure55 and mainly depends on β-oxidation to help meet this metabolic demand56. These characteristics may become more important with the activation of renal gluconeogenesis. Adiponectin plays a ...
Salicylates may reduce the tubular secretion of canrenone and decrease the diuretic efficacy of spironolactone, and spironolactone may alter the clearance of digitalis glycosides. Due to its steroid structure, spironolactone may cause gynecomastia, impotence, decreased libido, hirsutism, deepening of the ...
However, the current reported studies are all on patients with creatinine clearance rates above 40mL/min and no significant renal toxicity, but research conducted in patients with moderate or severe RI is worth looking forward to. Recent research identified through burst analysis of the references ...
However, the patient’s responsibility for chronic care, which therefore has a dual therapeutic and psychosocial objective, depends largely on its compliance with the timing imposed by telemonitoring and the sharing of responsibility for care. The benefits of time accountability are twofold. On ...
Since reproducibility of the protein pattern depends on the sample collection procedures, we optimized a urine handling protocol which allows fast collection and processing of urine leading to almost total inhibition of protein degradation and good reproducibility of the data. The mass spectra of the ...