Renal cell carcinomas (RCC) are a heterogeneous group of tumors whose pathological aspects, molecular pathways and genetic bases differ. Study of RCC familial predisposition syndromes has enabled a better understanding of activated molecular pathways. Five signalling pathways have emerged: VHL/HIF/VEGF ...
Renal cell carcinoma is the most common primary malignancy of the kidney. This tumor accounts for 2% of all cancer diagnoses in humans [1]. Among the RCC histologic subtypes, the vast majority are classified as clear cell renal cell carcinoma (CCRCC) [2]. Although renal tumors are usually ...
Diagnostic Pathology 2012;7: 21.Quiroga-Garza G, Pi帽a-Oviedo S, Cuevas-Ocampo K, Goldfarb R, Schwartz MR, Ayala AG, Monzon FA. Synchronous clear cell renal cell carcinoma and tubulocystic carcinoma: genetic evidence of indepepndent ontogenesis and implications of chromosomal imbalances in ...
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer. Prognosis for ccRCC is generally poor since it is largely resistant to chemo- and radiotherapy. Many studies suggested that cancer stem cells/tumor initiating cells (CSCs/TICs) are responsible for development of tumor, dise...
Purpose To investigate whether imaging features on multiphasic multidetector computed tomography (MDCT) can predict the loss of chromosome 8p in clear cell renal cell carcinomas (RCCs), a cytogenetic abnormality associated with a higher tumor grade and greater risk of recurrence. Methods With IRB appr...
Targeting apoptosis in clear cell renal cell carcinoma[J]. Biomed Pharmacother, 2024,175:116805. [2] Skinner DG, Colvin RB, Vermillion CD, et al. Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases[J]. Cancer, 1971,28(5):1165-1177. [3] Pin...
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, respectively, with matched bul...
The histologic diagnosis may be challenging as the presence of small blue cells on biopsy may be mistaken for a lymphoma involving the prostate or a small cell carcinoma of the prostate, diagnostic possibilities that are statistically ... S Logani,RA Cabrera,MB Amin - 《Pathology Case Reviews》...
Multilocularrenalcellcarcinomahasaggregatesof clear cells within theseptadividingcysticspaces. 多房性肾细胞癌的囊内有透明细胞的聚集,其间有分隔。 www.pathology.cn 7. ObjectiveTodiscussthediagnosis,treatmentsandthemechanismof themolecularbiologyformultiplerenalcellcarcinoma(RCC). ...
E. et al. Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis. Eur. Urol. 67, 740–749 (2015). Google Scholar Kroeger, N. et al. Metastatic non-clear cell renal cell carcinoma treated with targeted therapy agents: characterization of survival ...