Renal carcinoma is a vascular tumor and VEGF has been detected in high levels in the serum of patients with RCC. With elucidation of key molecular mechanisms of disease, vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptors (VEGFR) and target of the mTOR emerged ...
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunotherapy, and combination therapies. However, curative treatment, particularly for advanced-stage dise...
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunotherapy, and combination therapies. However, curative treatment, particularly for advanced-stage dise...
Tivozanib monotherapy outperforms combination therapy in post-ICI RCC Maria Chiara Masone Research Highlights11 Nov 2024Nature Reviews Urology Volume: 21, P: 706 X chromosome dosage shapes renal cell carcinoma risk Tiago Faial Research Highlights11 Sept 2024Nature Genetics ...
renal cell carcinomasorafenibsunitinibtargeted therapytemsirolimusBACKGROUND: The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically over the past few years. Sunitinib malate, sorafenib tosylate, bevacizumab +/- interferon-alfa, temsirolimus, and everolimus have improved clinical ...
Systemic therapy in metastatic renal cell carcinoma. World J Urol. 2016:1e10.Bedke J, Gauler T, Grunwald V, Hegele A, Herrmann E, Hinz S, Janssen J, Schmitz S, Schostak M, Tesch H, Zastrow S, Miller K (2017) Systemic therapy in metastatic renal cell carcinoma. World J Urol 35(2...
Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy has become a game-changing therapeutic approach revolutionizing the treatment setting of human malignancies, such as renal cell carcinoma (RCC). Despite the remarkable clinical activity of anti-PD-1 or anti-PD-L1 monoc...
If the results show that you have renal cell carcinoma, your doctor will find out what stage it’s in, so you can decide on the best treatment options. The stage of cancer depends on how large your tumor is and whether the cancer has spread to other parts of your body. You may have...
Renal cell carcinoma. Lancet 373, 1119–1132 (2009). Google Scholar Vera-Badillo, F. E. et al. Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis. Eur. Urol. 67, 740–749 (2015). Google Scholar Kroeger, N. et al. Metastatic non-...
Twenty patients with metastatic renal cell carcinoma and nine patients with minimal residual disease (MRD) but at high risk for recurrence following nephrectomy received weekly four milligram intradermal injections of purified RNA extracted from lymphoid organs of sheep immunized with human renal cell carc...