Four hundred and seventy-five renal cell carcinomas had a diameter >1 cm and 161 autopsies had a status after nephrectomy. The mean tumour diameter was 3.9±4 cm (median 2 cm). The average age of tumour patients at autopsy was 71.9±11 years. The mean age of patients after nephr...
The advent of PD1/PD-L1 inhibitors has significantly transformed the therapeutic landscape for clear cell renal cell carcinoma (ccRCC). This review provides an in-depth analysis of the biological functions and regulatory mechanisms of PD1 and PD-L1 in ccRCC, emphasizing their role in tumor immune ...
renal cell carcinomaSonic HedgehogpatchedsmoothenedPROGNOSISGROWTHClear cell renal cell carcinoma (ccRCC) is the deadliest neoplasm of the urinary tract, and we are still far from completely understanding ccRCC development and treatment. The renal tissue paraffin blocks (20) of patients with ccRCC were...
Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable in ccRCC. Reproduction of public datasets with validation using microarray was performed to identify candidate
The remaining 10 % of KCa cases are primarily transitional cell carcinoma which mostly develop in the lining of the renal pelvis [4]. Almost all renal pelvis cancers are of the transitional cell type [3]. Wilms' tumor, also known as nephroblastoma, represents the predominant type of KCa...
renal cell carcinoma; inflammation; immune cells; anti-inflammatory therapies 1. Introduction Renal cell carcinoma (RCC) accounts for 95% of kidney-related malignancies and is considered a heterogeneous group of diseases that are classified according to their histological characteristics [1,2]. The ...
International Journal of Molecular Sciences Article Role of Nuclear Claudin-4 in Renal Cell Carcinoma Takuya Owari 1,2, Takamitsu Sasaki 1, Kiyomu Fujii 1, Rina Fujiwara-Tani 1, Shingo Kishi 1, Shiori Mori 1, Takuya Mori 1, Kei Goto 1, Isao Kawahara 1, Yasushi Nakai 2, Makito Miyake 2...
Regarding DM, adenosquamous carcinoma had an odds ratio of 363, BSCC an odds ratio of 680, and spindle cell carcinoma (SpCC) an odds ratio of 391. A poor OS outcome was significantly associated with SpCC, displaying a hazard ratio of 161.The heterogeneity of DM rates was evident amongst ...
Regarding DM, adenosquamous carcinoma had an odds ratio of 363, BSCC an odds ratio of 680, and spindle cell carcinoma (SpCC) an odds ratio of 391. A poor OS outcome was significantly associated with SpCC, displaying a hazard ratio of 161.The heterogeneity of DM rates was evident amongst ...
[33]. As for the incidence rate, the papillary cell type is secondary to the clear cell type, accounting for about 50% of non-clear cell renal cell carcinoma, and the clinical management of this disease is similar to that of the clear type; for patients in early-stage, radical operation...