Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable in ccRCC. Reproduction of public datasets with validation using microarray was performed to identify candidate
Dannenmann SR, Thielicke J, Stockli M, Matter C, von Boehmer L, Cecconi V, Hermanns T, Hefermehl L, Schraml P, Moch H, Knuth A, van den Broek M (2013) Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma. Oncoimmun...
METHODS: Newly diagnosed, histologically confirmed adenocarcinoma of the renal parenchyma (renal cell carcinoma (RCC)) cases (n ¼ 1192) were frequency matched on age, sex, and race to controls (n ¼ 1175). The interviewer-administered Diet History Questionnaire (DHQ) included queries for ...
renal cell carcinoma; inflammation; immune cells; anti-inflammatory therapies 1. Introduction Renal cell carcinoma (RCC) accounts for 95% of kidney-related malignancies and is considered a heterogeneous group of diseases that are classified according to their histological characteristics [1,2]. The ...
[33]. As for the incidence rate, the papillary cell type is secondary to the clear cell type, accounting for about 50% of non-clear cell renal cell carcinoma, and the clinical management of this disease is similar to that of the clear type; for patients in early-stage, radical operation...
Regarding DM, adenosquamous carcinoma had an odds ratio of 363, BSCC an odds ratio of 680, and spindle cell carcinoma (SpCC) an odds ratio of 391. A poor OS outcome was significantly associated with SpCC, displaying a hazard ratio of 161.The heterogeneity of DM rates was evident amongst ...
Regarding DM, adenosquamous carcinoma had an odds ratio of 363, BSCC an odds ratio of 680, and spindle cell carcinoma (SpCC) an odds ratio of 391. A poor OS outcome was significantly associated with SpCC, displaying a hazard ratio of 161.The heterogeneity of DM rates was evident amongst ...
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer...
Reanalysis of publicly available data from The Cancer Genome Atlas (TCGA) revealed that NOTCH3 mRNA was expressed most strongly in clear cell renal cell carcinomas (Figure 1C). 2.2. Ectopic Notch3 Signaling Activation Compromises Renal Function and Increases Kidney Size We have previously generated...
Renal cell carcinoma (RCC) is the most common RC type [7], with clear cell RCC (ccRCC) subtype encompassing approximately 75% of all RCC, followed by papillary RCC (pRCC) and chromophobe RCC (chRCC), which constitute approximately 10% and 5% of all cases, respectively [8]. This review...