The article reports on the stratification of renal cell cancer (RCC) prognosis before and after nephrectomy. According to the author, enhancing prognostic stratification after nephrectomy is important for the right surveillance and clinical trial design. The TNM staging criteria will continue to evolve ...
摘要: Background: Cancer-associated fibroblasts (CAFs) are mainly involved in cancer progression and treatment failure. However, the specific signature of CAFs and th关键词: renal cell carcinoma cancer-associated fibroblast weighted gene co-expression network analysis single sample Gene Set Enrichment ...
targeting the clearance of senescent RTEC, or promoting the apoptosis of senescent RTEC hold promise for enhancing the renal prognosis of AKI. This review primarily focuses on the characteristics and mechanisms of RTEC senescence, and the impact of intervening RTEC senescence on the prognosis...
Clear cell renal carcinoma (ccRCC) is the most common phenotype of kidney cancer, occurring in 70% to 75%, which is strongly associated with von Hippel-Lindau (VHL) gene mutation [3]. Systemic treatment of ccRCC has rapidly evolved in recent years, especially for patients with metastatic ...
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and accounts for >90% of cancers in the kidney. The disease encompasses >10 histological and molecular subtypes, of which clear cell RCC (ccRCC) is most common and accou
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer. Prognosis for ccRCC is generally poor since it is largely resistant to chemo- and radiotherapy. Many studies suggested that cancer stem cells/tumor initiating cells (CSCs/TICs) are responsible for development of tumor, dise...
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment wit...
FULL PAPER British Journal of Cancer (2013) 108, 901–907 | doi: 10.1038/bjc.2013.28 Keywords: prognosis; renal cell carcinoma; validation study Validation of the pre-treatment neutrophil–lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients M ...
3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketone body synthesis, and most current studies focus on mitochondrial maturation and metabolic reprogramming. The role of HMGCS2 was evaluated in a pan-cancer multi-database
Renal cell cancer 8p21 deletion Fluorescence in situ hybridization Tissue microarray Prognosis 1. Introduction In 2012, approximately 84,400 new cases of renal cell carcinoma (RCC) have been diagnosed in the European Union and cancer related deaths were estimated at 34,700 [1]. Over the past de...