The article reports on the stratification of renal cell cancer (RCC) prognosis before and after nephrectomy. According to the author, enhancing prognostic stratification after nephrectomy is important for the right surveillance and clinical trial design. The TNM staging criteria will continue to evolve ...
Renal cell carcinoma (RCC) represents approximately 3% of adult cancers and has been widely recognized as a heterogeneous disease encompassing different subtypes [1]. About 70–80% of RCC cases have clear cell histology (ccRCC) [1,2], which has a relatively poor prognosis, with 30% of patien...
Cell proliferation in renal cell carcinoma : a clinical study with special reference to prognosis Four different methods of cell proliferation (S-FCM, IdUrd-IHC, IdUrd-FCM, PCNA-IHC) were compared. Comparative analysis according to the Bland and ... P Larsson - 《Scandinavian Journal of Urolog...
0007 – 0920/12 www.bjcancer.com Editorial Second-line treatment for renal cell cancer G Di Lorenzo*,1, S De Placido1 and C Buonerba1 1Dipartimento di Endocrinologia ed Oncologia Clinica e Molecolare, Universita` Federico II, Napoli, Italy British Journal of Cancer (2012) 106, 617 – 618...
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment wit...
Ultimately, improving the long-term prognosis ccRCC will require personalized treatment strategies specific to the biology of each tumor. CSCs have been characterized in many cancers and implicated in resistance to treatment, tumor recurrence, and metastatic spread; the situation in kidney cancer has ...
REVIEW British Journal of Cancer (2016) 115, 505–516 | doi: 10.1038/bjc.2016.230 Keywords: systemic therapy; metastatic renal cell carcinoma; T-cell checkpoint inhibitors; tyrosine kinase inhibitors Medical treatment of renal cancer: new horizons Basma Greef*,1 and Tim Eisen2 1Department of ...
The clinical presentation of renal cell cancer (RCC) is shifting towards incidental and early detection, creating new challenges in RCC diagnosis. Overtreatment might be reduced with the development of new diagnostic biomarkers to distinguish benign from malignant small renal masses (SRMs). Differently ...
Keywords Clear cell renal cell carcinoma Genomic mutation Immune checkpoint therapies Prognosis Tumor microenvironment 1. Introduction Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system, accounting for 3% of all malignant tumors, and its incidence is increasing at the rate of...
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and accounts for >90% of cancers in the kidney. The disease encompasses >10 histological and molecular subtypes, of which clear cell RCC (ccRCC) is most common and accou