The authors also express their gratitude to the entire team at the Cancer Center in Chang Gung Memorial Hospital for their indispensable assistance. Funding This work was supported by grants from the Chang Gung Medical Research Fund (CORPG3G0051, CGMH-NTUT-106-No.06) and the National Science ...
The asymptomatic nature of clear cell renal cell carcinoma (ccRCC), the most common renal cancer, often leads to diagnosis in late III or IV stage with survival probability of 59% and 20%, respectively, also, ~30% of cases metastasize1. Previous efforts aimed at characterizing ccRCC tumors h...
In principle, tumor progression can be regulated by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve various mechanisms that mimic peripheral immune tolerance for deterring tumoricidal attack. Intrinsic mec...
The UPR enforces adaptive or cell death programs by integrating information about the intensity and duration of stress stimuli [64]. One of our important findings is that APOL1 localizes to the ER in renal cancer. RNA-seq data and subsequent gene ontology (GO) enrichment analysis showed that...
DCCD cancer cells are characterized by fewer lipid droplets, reduced metabolic activity, enhanced nutrient uptake capability and a high proliferation rate, leading to poor prognosis. Using single-cell and spatial trajectory analysis, we demonstrate that DCCD is a common mode of ccRCC progression. Even...
(ICs), the putative cellular origin of chRCC36,50and is more highly expressed in chRCC than other cancer subtypes in the TCGA dataset (Supplementary Fig.S7A). We also manipulated the expression ofEPAS1as a second target as it was highly specific for ccRCC in our integrative analysis (Fig...
Competing interests The authors declare that they have no competing interests. Funding/assistance was not received from a commercial organization.Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ...
Also necessary is assistance for home-schooled children and strengthening the social fabric of local neighborhoods.Intersectoral partnerships' co-production of 'synergistic' solutions for complex public health problems dramatically outperforms the achievements of any individual organization. Equitable co-...
(RCC). Despite the remarkable clinical activity of anti-PD-1 or anti-PD-L1 monoclonal antibodies, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy, and the primary or acquired resistance might ultimately favor cancer development in patients with ...
Bristol, Bristol, UK; 3Medical Development, Amgen (Europe) GmbH, Vienna, Austria; 4Medical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy Abstract: Renal function is an important consideration in the management of patients with advanced cancer. Ther...