Diagram of renal hemodynamic mechanisms. a Reduction in mean arterial pressure (MAP) or cardiac output (CO), which determines renal preload, leads to decreased renal blood flow (RBF). This triggers an increase in renal arteriolar resistance (RRI), abnormally high in this context, resulting in ...
With solely the myogenic response, our model had a maximum deviation of 7% in change in renal blood flow and 7% in renal vascular resistance. When both the myogenic response and tubulo- glomerular feedback were concurrently activated, the maximum deviation was 7% in change in renal blood flow...
shows the global interpretation of the SHAP Beeswarm diagram Full size image Fig. 7 Individual prediction of the model using the SHAP plot method. A.Patient A has high-grade ccRCC B. Patient B has low-grade ccRCC Full size image Discussion In this study, a radiomics ML model was developed...
FIG. 10 provides a control-flow diagram of the quantitative-renal-assessment method that represents one embodiment of the present invention. In step 1002, a time series of MRIs is acquired from a patient. Next, in step 1004, the volume of voxels within each of the MRIs corresponding to the...
It is possible that these simplified assays failed to reproduce the metabolic conditions that are present in vivo. It is also likely that many other complex factors such as the presence and activation states of other immune microenvironmental cells (such as macrophages, MDSCs, dendritic cells, and...
Flow diagram depicting patient recruitment numbers and exclusion criteria. ESKD = End Stage Kidney Disease, AVF = Arteriovenous fistula, AVG = Arteriovenous graft, RRT = Renal Replacement Therapy Full size image Table 1 Patient profile and subgroup comparisons (mortality versus survivo...
Search synthesis. PRISMA flow diagram. The PRISMA Statement and the PRISMA Explanation and Elaboration document are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source...
b. Preservation of renal blood flow sufficient to preserve renal function. c. Reduction of progressive damage to the kidney from high pressure, hyperfiltration and proteinuria. Extension of life free of dialysis. d. Reduction of renin secretion from the protected kidney, reduction of afferent sympat...
(a) The components of microfluidic cell chip laboratory include ① controller ② chip culture plate ③ manifold ④ control software; (b) Microfluidic structure and flow diagram of manifold; (c) The working design of Cellasic M04S culture plate; (d) The structure diagram of cell culture ...
However, the disturbance (impairment) of microvascular blood flow up to a certain point may not be reflected by the changes in macrohemodynamics [204]. The development of microthrombus formation (particularly intense in postcapillaries) or, otherwise, disseminated intravascular coagulation (DIC) is ...