Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumo
One of the major limitations of human studies is that tendon biopsies are usually obtained when patients are symptomatic and therefore biopsy material is likely to represent chronic, rather than early phase processes. We previously suggested that matched subscapularis tendon from patients with full thic...
Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell...
The percentage of S phase in cell cycle was significantly decreased in MTDH- overexpressing cells. Data are mean±s.d. *Po0.05 compared with vector control cells. Figure 3. Cell migration and invasion were suppressed and actin cytoskeletal remodelling was regulated by MTDH expression in vitro. (...
In comparison to rHCIII matrices, rHCI matrices were therapeutically more significant to avert LV remodelling when applied in the late proliferative phase post-MI [150]. Another research group employed sericin, a silk-derived protein used as a wound-healing agent, for the first time. Genipin-...