Remodeling the Blood Coagulation Cascade The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but has flaws as a model of the hemostatic process ... M Hoffman - 《Journal of Thrombosis & ...
All resting ECGs and blood sampling were performed after the participants had been in a semi-recumbent position for approximately 30 min. Upon the completion of all the assessments, the participants received breakfast and feedback and were then transported back to their respective schools. Lifestyle...
8] identified that autophagy plays a pivotal role in blood cell cortical remodeling, with involvement in the extension of cell protrusions, such as lamellipodia and filopodia. Rapamycin is a kind of autophagy agonist, which was reported to be associated with regulation of endothelial cytoskeleton 9...
26,27, or in injured brains14,15, we next investigated the impact of increased microglia phagocytosis on engulfment and clearance of the injured synaptic structures at the acute post-stroke phase and on the chronic post-stroke synapse remodeling. C1q is the initiating ...
(2007). Surface plasmon resonance detection of blood coagulation and platelet adhesion under venous and arterial shear conditions. Biosens Bioelectron 23, 261–8 Article Google Scholar Helmke, B. P. (2005). Molecular control of cytoskeletal mechanics by hemodynamic forces. Physiology (Bethesda) 20,...
AF induces hypercoagulability; however, the role of the coagulation cascade components in promoting AF remodeling is less known. The presence of low voltage LA areas correlated with 30 differentially abundant proteins of the coagulation and complement cascades (q < 0.05) in an untargeted proteome an...
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc. Natl. Acad. Sci. USA 2007, 104, 6388–6393. 21. Semeraro, F.; Ammollo, C.T.; Morrissey, J.H.; Dale, G.L.; Friese, P.; Esmon, N.L.; Esmon, C.T. Extracellular histones promote thrombin ...
Another vasculature-like structure could also support tumors with blood, which is called vasculogenic mimicry constructed by cancer cells without endothelial cells. The primary trigger is dense collagen, inducing cancer cells to form interconnected networks [4]. Velez et al. found that the collagen ma...
First, to prevent bleeding caused in the early stages of tissue damage, the coagulation cascade is activated to create a blood clot and perform hemostasis. Subsequently, an inflammatory step occurs to prevent infection at the wound site. Fibroblasts, which quiescently reside in connective tissue ...
Within blood vessels, ROS are produced by all the cellular components of the vascular wall including endothelial cells, smooth muscle cells, fibroblasts and immune cells. Accumulating evidence indicates that ROS serve as signaling molecules that modulate acute vascular functions such as vasodilation, ...