As with all therapeutic proteins, there is potential for immunogenicity. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay. Additionally, the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by...
Well, when you diminish the activity of the immune system, these are the potential consequences. And it seems ironic that doctors try toIMPROVEthe activity of the immune system in those with HIV in order toPREVENTthese same illnesses, while diminishing the immune system so much in those withCr...
A 6-month study in CD-1 mice was conducted to assess the tumorigenic potential of cV1q anti-mouse TNFα, an analogous antibody. No evidence of tumorigenicity was observed in mice that received intravenous doses of 10 mg/kg or 40 mg/kg cV1q given weekly. The relevance of this study ...
Both new drug classes have the potential for superior efficacy and improved tolerability profiles when compared with traditional PsA treatments. Furthermore, the biologics may possibly have a better overall safety profile than conventional treatments. Moreover, unlike older, conventional PsA treatments, ...
June 16th 2024 Podcast In this episode, The Center for Biosimilars® delves into the FDA approval of the first denosumab biosimilars, Wyost and Jubbonti (denosumab-bbdz), and discuss their potential to revolutionize osteoporosis treatment with expert insights from 2 rheumatologists. ...
whereas the rate in control patients was lower than expected. Cases of acute and chronic leukemia have been reported with postmarketing TNF-blocker use. As the potential role of TNF inhibitors in the development of malignancies is not known, caution should be exercised when considering treatment of...
Both new drug classes have the potential for superior efficacy and improved tolerability profiles when compared with traditional PsA treatments. Furthermore, the biologics may possibly have a better overall safety profile than conventional treatments. Moreover, unlike older, conventional PsA treatments, ...