Clonazepam (Klonopin) is highly effective in the treatment of REM sleep behavior disorder (RBD), relieving symptoms in nearly 90% of patients with little evidence of tolerance or abuse. The response usually begins within the first week, often on the first night. The initial dose is 0.5 mg at...
REM sleep behavior disorder (or RBD) is truly one of the most intriguing, and indeed troublesome, sleep disorders known to man.In essence, it causes the afflicted individual to act out their dreams to some extent. Can you imagine that?! Thinking about some of the dreams I've had, I ...
Idiopathic rapid eye movement (REM) sleep behavioural disorder (RBD) is now recognized as an early marker of α-synucleinopathies. Here, Högl and colleagues review potential biomarkers for RBD and summarize the evidence for a prodromal stage, which mi
A 55 year old female with a past medical history significant for Parkinson disease status-post implantation of bilateral deep brain stimulators, depression, and restless legs syndrome, who initially presented to the sleep clinic on referral by neurology for evaluation of disordered sleep. Medications ...
Presence of REM sleep without atonia (RSWA) on polysomnography (PSG) Sleep disorder not better explained by another sleep disorder, a medical or neurologic disorder, a mental disorder, medication use, or a substance use disorder Next: Etiology What to Read Next on Medscape Related Conditions ...
The key words for the searches were the following: (RBD OR REM Sleep behavior disorder) and treatment, behavioural modification, medication, drug therapy including key pharmacological names. As well as associations with neurological disorders such as Parkinson's, synucleinopathies, narcolepsy, ...
Parkinson’s disease (PD) is a progressive neurodegenerative disease that is caused by a loss of neurons in the ventral midbrain. Parkinsonian patients often experience insomnia, parasomnias, and daytime somnolence. REM sleep behavior disorder (RBD) is characterized by vigorous movements during REM...
We analyzed 107 full-night recordings from 55 subjects: 24 healthy adults, 28 Parkinson’s disease patients (15 RBD), and three with isolated Rem sleep behavior disorder (RBD). Sessions were manually scored. An automatic algorithm for quantifying RSWA was developed and tested against manual ...
REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid with PD have more affected striatal dopamin
Despite decades of research, there is a persistent debate regarding the localization of GABA/glycine neurons responsible for hyperpolarizing somatic motoneurons during paradoxical (or REM) sleep (PS), resulting in the loss of muscle tone during this slee