The monophasic release of insulin triggered by tolbutamide (100 μg/ml) at low glucose could be evoked again by removing and reintroducing the drug, or by temporarily withdrawing calcium or adding cobalt to the medium. Tolbutamide (20 μg/ml) accelerated and potentiated the biphasic insulin ...
We have also shown that the rapid tPA release can be triggered by redox reactions, including oxidation of the NADPH or the reduction of the disulfide bonds in the longer peptides. These reactions lead to the dissolution of the coacervates, triggering the subsequent release of the tPA. Taken ...
In response to a rapid increase in D-glucose concentration, the release of insulin exhibits a multiphasic pattern. An almost immediate peak of insulin release is followed by a lower, but higher than basal, insulin output. Thereafter, a progressive rise in the rate of insulin secretion is observ...
1a). Immunofluorescence staining of slices prepared from pancreatic islets from α-GsD mice confirmed the expression of GsD in glucagon-expressing α-cells and the lack of GsD expression in insulin-containing β-cells or other islet cells (Supplementary Fig. 1b). As expected, GsD was not ...
most of the drugs do not require constant drug concentration to be maintained because the efficacy of the drug is the same when the concentration of the drug is above the minimum effective level and below the maximum safe concentration; for example, nitroglycerine and insulin. It took several y...
Moreover, glucose-triggered on–off release of insulin was obtained under physiological pH 7.4 with 2 g L1glucose (hyperglycemia), which provided us with an effective strategy for self-regulated insulin delivery in response to physiological glucose level. The enhanced biocompatibility of this complex ...
The effects of epinephrine on insulin release, 86Rb+ fluxes, and 45Ca2+ fluxes were measured in rat islets. In the presence of 10 mM glucose, epinephrine did not affect 86Rb+ influx and slightly increased net uptake. It caused a monophasic inhibition of release and a biphasic decrease in ...
Estrus is caused by a release of which sex hormone into the bloodstream? a. androgen b. noradrenaline c. oxytocin d. estrogen Estrus: The estrus cycle is the monthly fertility cycle of many female mammals. This cycle happens in both humans ...
Molecular determinants of regulated exocytosis. (Section 1: insulin release: some molecular requisites)Regulated exocytosis forms the basis for many intercellular signaling processes, for example, in hormone secretion or neurotransmitter release. During regulated exocytosis, the membrane...
The release rate of a growth factor protein was the same as that of dextran with the same molecular weight. Cell growth was enhanced in response to a sustained release of insulin-like growth factor-1 from the F-Alginate hydrogel. This is a preview of subscription content, access via your ...