GENOMIC imprinting, or parental allele-specific expression of genes, has been demonstrated at the molecular level in insects and mice 1,2 but not in man. Imprinting as a potential mechanism of human disease is suggested by paternal uniparental disomy of 11 p15 in Beckwith–Wiedemann syndrome 3 ...
The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishable female mouse embryonic stem cell (mESC) system, Xmas, that allows rapid assessment of X chromosome inactivation (XCI), th
Relaxation of imprinted genes in human cancer. Nature 1993;362(6422):747-9.Rainier S,Johnson LA,Dobry CJ,et al.Relaxation of imprinted genes in human cancer. Nature . 1993Rainier S,Johnson LA,Dobry CJ,et al.Relaxation of imprinted genes in human cancer.Nature. 1993...