Power was computed using TDT Power Calculator [15] varying SNP minor allele frequency (MAF) and genetic relative risk (GRR).doi:10.1371/journal.pone.0104212.t004E. K. AllenA. ManichaikulWei-Min ChenS. RichK. DalyM. SalePLOS ONE
The β-thalassemias are an increasing challenge to health systems worldwide, caused by absent or reduced β-globin (HBB) production. Of particular frequency in many Western countries is HBBIVSI−110(G > A) β-thalassemia (HGVS name: HBB:c.93-21G > A).