In the electron microscope, ER were of two types: the heavily granulated, flattened, rough ER seen in the infranuclear and juxtanuclear regions and the distended, tubular, sparsely granulated ER, showing only few ribosomes, seen interlaced with the Golgi ribbon in the supranuclear region and at...
Tight contacts between the ER and the mitochondria were originally observed in 1956 on electron micrographs of the rat liver13. The characterization of the MAMs has been refined and now relies, in addition to electron microscopy, on biochemical methods, such as cell fractionation14,15, and fluores...