Leveraging biomarker data andcis-instrument MR29, we performed a screen of several thousand protein-coding genes located near the genomic loci of the biomarkers, that is, HbA1c, HDL-C, LDL-C, TG and SBP, corresponding to the physiological responses to glucose-lowering, lipid-modulation and ant...
The aorta is the largest artery in the human body and its main function is to take up all the blood ejected by the left ventricle and to conduct it to the branches leading to all parts of the body (Kassab 2007; Wang et al. 2023). Since, the heart beats ceaselessly, the aorta faces...
Arete, as the Greeks called the search for excellence, and, as my philosopher brother Steve would remind me, is the notion of the fulfillment of purpose or function: the act of living up to one’s full potential. If you put in the necessary hard work, have reached your full potential...
During oxidative phosphorylation, mitochondria continuously produce reactive oxygen species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress, ultimately resulting in mitochondrial damage. Mitophagy is essential for maintaini
Background-Coronary endothelial function is abnormal in patients with established coronary artery disease and was recently shown by MRI to relate to the severity of luminal stenosis. Recent advances in MRI now allow the noninvasive assessment of both anatomic and functional (endothelial function) change...
During oxidative phosphorylation, mitochondria continuously produce reactive oxygen species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress, ultimately resulting in mitochondrial damage. Mitophagy is essential for maintaini
Video S1. Three-dimensional confocal image of MC4R + primary cilia and α-MSH-containing axons in the DMH, related to Figure 1D Document S1. Figures S1–S7 and Table S1 Data S1. Unprocessed data underlying the display items in the manuscript, related to Figures 1, 2, 3, 4, 5, 6,...
We compared health-related quality of life (HRQL), including patient-perceived neurocognitive function at preoperative baseline and 3 months after coronary artery bypass (CABG) surgery.DesignThe design was prospective and comparative.SettingThe study took place in the cardiovascular units at two large ...
Diabetic foot ulcers (DFU) is the most serious complication of diabetes mellitus, which has become a global health problem due to its high morbidity and disability rates and the poor efficacy of conventional treatments. Thus, it is urgent to identify nov
to proper CNS integrity in both the healthy brain and neuropathologies [3]. Microglia are the main constituent of the innate immune system in the brain, affecting CNS function and governing neuroinflammation [4]. For instance, infections, trauma [5], ischemia [6], and toxins [7] lead to ...