Ischemic stroke (IS) is the fourth most burdensome neurological disorder [1] and the third leading cause of death worldwide [2], resulting from an abrupt blockage of the cerebral artery. To date, there are no acknowledged or authorized biomarkers for IS, and we are still making efforts to...
Thecentral retinal arteryis the main vessel that supplies blood to the retina. This artery can become completely blocked by an embolism or thrombosis (formation of a blood clot in the artery). Blockage may occur in the main artery or in its branches. (See alsoOverview of Retinal Disorders.)...
(false) lumen can cause a blockage or a complete closure of an artery that branches out of the aorta leading to a decreased perfusion in the terminal tissue, or (2) the crack tip can propagate through the weakened aortic wall in a radial direction to the tunica adventitia until it reaches...
or ST elevation myocardial infarction heart attack, there is a complete blockage of an artery supplying blood to the heart. With a NSTEMI, or non-ST elevation myocardial infarction heart attack, there is no ST elevation, but there is typically a significant ...
Afterwards, cerebral I/R model rats were established by a middle cerebral artery occlusion surgery. Neurological deficits, histopathology, and cerebral infarction volume were used to evaluate the effects of YQXN. Evans blue and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL...
K+ and Cl– channels have been found to assist with Ca2+ entry by main- taining a sufficiently negative membrane potential[37]. Therefore, it is reasonable to suggest that Cl– channels may be involved in T cell activation by regulation of the CRAC channels. Our data also indicated that ...
2. A brief introduction to the TRPM2 channel 3. Deletion of the TRPM2 expression halts Aβ-induced neurodegeneration and cognitive impairment in an AD mouse model 4. TRPM2 channel as part of a positive feedback loop for Aβ42-induced neuronal death 5. TRPM2 channel in Aβ42-induced micr...
These include, direct inhibition of sense transcription via antisense hybridization to RNA; induction of DNA methylation for gene silencing by antisense mediation; blockage of RNA splicing, processing, stability and miRNA binding sites via antisense/sense hybrids; DICER targeting and processing of ...
[112]. In addition, structural similarity has been identified between hepcidin and SARS‐CoV‐2 spike protein. It has been hypothesized that the viral spike protein may have a hepcidin-mimetic action and induce ferroportin blockage [81]. If correct, then this can further promote intracellular ...
ADP-ribosylation at this site results in steric hin- drance of actin monomer interactions and blockage of polymerization. Mutagenesis of R179 to D in β-actin has been shown to significantly lower polymerization rate and polymer viscosity [21], suggesting a critical role in actin polymerization. ...