Researchers analyzed the properties of MCT1 to consider the possibility as an effective therapeutic strategy. Therefore, research on cell biology, biochemistry, and molecular biology also increased rapidly. In the MCT1 research field, a multi-interdisciplinary system has been formed with oncology as ...
In previous studies, m6A modification of RNA were proved to play an important role in tumorigenesis and metastasis. Wen et al. found that m6A on ncRNA NEAT1-1 plays a critical role in the pathogenesis and development of bone metastatic prostate cancer [8]. Chang et al. demonstrated that ...
Silver nanoparticles (AgNPs) modified with sodium 2-mercaptoethanesulfonate showed strong SERS, while an intensity decrease of SERS is observed in the presence of Hg2+ due to the strong covalent bonding of mercury and sulfur [44]. Methimazole-functionalized and cyclodextrin-coated silver nanoparticles...
In contrast to OA patients, the level of expression of Runx2 was very weak in chondrocytes from patient "Patient 4" who had bone necrosis of the femoral condyle (Figure 2A). The degree of Runx2 expression in chondrocytes was associated with the severity of cartilage degeneration and osteophyte...
Both forms of vitamin D are then converted to 25(OH)D3 in the liver, which is further converted in the kidneys to 1,25(OH)2D3 by 1-alpha-hydroxylase. This active form of vitamin D, 1,25(OH)2D3, promotes calcium absorption in the small intestine, increases bone mineralization through...
We also measured the radical scavenging activity of Pp-EE to determine its antioxida- tive capacity. First, an 2,2 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) assay was conducted. ABTS oxidized by potassium persulfate or manganese dioxide produces bluish-green ABTS•+ radicals,...
In addition to Th1 cells, Th17 cells, recognized as active players of chronic inflammatory and autoimmune diseases, have been recently found to play an important role in obesity and T2D (as reviewed below). Because obesity appears to exacerbate chronic inflammatory diseases, autoimmune diseases and ...
To identify the unstable reaches in streams, an evaluation system based on the integrated model that can provide the bed erosion and deposition patterns, flow-induced shear stress on the bed and bank of streams, and possibility of slope failure near the streams was developed. The integrated ...
The substances modulated the expression of catabolic and anabolic genes in chondrosarcoma cell line SW1353 and in primary human chondrocytes that were stimulated by IL-1β (i.e., chronic inflammation In SW1353, catabolic genes like MMP-13 and ADAMTS-4 that contribute to cartilage erosion were ...
Different devices employ unique calculation methods to analyze OCT intensity infor- mation. Algorithms used by OCTA systems can be divided into three categories: (A) an- giography based on both the phase and amplitude components of the OCT signal (OMAG or OCT microangiography-complex; CODAA, ...