Antibodies that are indicative of organ transplant rejection, for example, cardiac or kidney transplant rejection, and of associated pathological conditions, for example, accelerated (or transplant-associated) coronary artery disease (CAD) are identified, as are antigens that bind to such antibodies. ...
REJECTION REACTIONS TO DIFFERENT ORGAN TRANSPLANTS P. J. FRIEND Cambridge Rejection of solid organ grafts is conventionally classified as hyperacute, acute and chronic. Hyper acute rejection is the consequence of preformed antibodies in the serum of the recipient which recognise donor antigens. ...
Morelli1,5,** Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to graft failure. Here we demonstrate that ...
primarily occurs in recipients ofbone marrow transplantsand peripheral blood stem cells. GHVD presents a unique situation because the transplanted tissue is capable of producing immune cells; APCs in the donated bone marrow may recognize the host cells as non-self, leading to activation of the ...
建築師吹噓塔』地熱井,並且其他講究eco特點,做它一世界的最大的「綠色」住宅項目。 北京。 相片由作者。[translate] ai dream your dreams 正在翻译,请等待...[translate] aCiclosporin - used to stop the rejection of organs after a transplant Ciclosporin -曾经在移植以后停止器官的拒绝[translate]...
xenotransplant, xenotransplantation - a surgical procedure in which tissue or whole organs are transfered from one species to another species 3. transplant - the act of removing something from one location and introducing it in another location; "the transplant did not flower until the second year...
The continuing search for more selective and specific agents has become, in the past decade, one of the priorities for transplant medicine. Some of these compounds are now entering routine clinical practice: among them are tacrolimus (which has a mechanism of action similar to that of cyclosporin...
of cytokines that are responsible for triggering autoimmune diseases. Pharmaceutical immunoproteasome inhibitors, which are presently tested in a first clinical trial, might allow us to fight autoimmune diseases and prevent the chronic rejection of transplant organs without compromising the patients' entire ...
Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples) from four organs, we identified a common rejection module (CRM) con... P Khatri,S Roedder,N Kimura,... - 《Journal of Experimental Medicine》 被引量: 128发表: 2013年 Pharmaceuticals for the treatment of...
The very first successful kidney transplant operation worked because the donated kidney came from the patient's identical twin. While this was a breakthrough, it was not a solution - not everyone has an identical twin with organs to spare. ...