Regulatory T-cell therapy for inflam- matory bowel disease: more questions than answers. Immunology 2012; 136: 115-122Himmel ME, Yao Y, Orban PC, Steiner TS, Levings MK. Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers. Immunology 2012; 136: 115-122 [...
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune homeostasis. Accordingly, deficiencies in Treg cell development or function result in uncontrolled immune responses and tissue destruction and can lead to ...
Regulatory T-cells (Tregs) are a type of white blood cell that suppresses the body’s immune response and prevents unnecessary inflammation. Tregs are part of the immune system and can enter the brain and the spinal cord to reduce neuroinflammation....
Although promising, human Treg cell infusion therapy has heretofore been difficult to implement in the clinic, and relatively few clinical trials have been initiated. This review will focus on the preclinical models that provide the rationale for current trials and it will address both the ...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-lin...
Regulatory T cells (TReg cells) are a special subset of T cells that prevent other immune cells from attacking the body’s own tissues and other harmless environmental materials, such as food and commensal organisms. Defects in regulatory T cells cause severe inflammatory disease. ...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-lin...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendo...
Treg therapy using cells expanded ex vivo using everolimus is being investigated in a pilot study (NCT03284242) [16]. While previous clinical trials have excluded highly sensitised patients, GAMECHANgER-1 is an ongoing phase 2a study testing the effects of apTregs on memory T and B cell ...
plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and...