Journal of Comparative Physiology BMeinardus-Hager G, Gabbott PA, Gäde G (1989) Regulatory steps of glycolysis during environmental anoxia and muscular work in the cockle, Cardium tuberculatum: control of low and high glycolytic flux. J Comp Physiol B 159:195–203...
Following activation, conventional T (Tconv) cells undergo an mTOR-driven glycolytic switch. Regulatory T (Treg) cells reportedly repress the mTOR pathway and avoid glycolysis. However, here we demonstrate that human thymus-derived Treg (tTreg) cells can
The transient hybridization of RNA:DNA results in the formation of R-loops, which displace single-stranded DNA, an essential structure for genome-wide regulation, particularly the regulation of chromatin dynamics and transcription. Enriched R-loops can be observed at active genes across the genome, ...
These can be classified as pathway-specific and pathway-non-specific, which generally include enzymes involved in biosynthetic steps overlapping different glycosylation classes, such as elongation/branching and capping/terminal modifications (Fig. 6a). Transcriptional analysis by Real-time PCR showed that ...
In choosing an asymmetric route based on a sulfinamide auxiliary, the team added 2 steps (the installation and removal of the chiral auxiliary). By doing so, the desired chiral product P37 was prepared directly and avoided wasting valuable material on preparation of the opposite enantiomer. In ...
(Fig.4F). In LW piglets, an overall increase in the expression of these essential genes related to β-oxidation and TCA cycle, in particular, such asACADSandCS, the enzymes that catalyze the rate-limiting steps of short-chain fatty acid dehydrogenation in the large intestines [72]. Our ...
[42]. Moreover, the BRPF3 scaffold specifically guides HBO1 to H3K14ac, promoting the loading of CDC45 to activate DNA replication in the S phase [1]. Thus, through collaboration with different scaffolds, HBO1-mediated chromatin acetylation facilitates two consecutive steps in replication ...
Among these regulated signaling pathways, they mainly focused on the PPAR signaling, pyruvate metabolism, propanoate metabolism, ascorbate and aldarate metabol- ism, glycolysis/gluconeogenesis, GABAergic synapse and TGF-beta signaling pathways (Fig. 5, Additional file 5 Table 4). Expression of PPAR-...
Gly- colysis is a catabolic process that converts glucose into pyruvate via 10 enzymatic steps [44]. Strikingly, 5 out of the 10 key enzymes required for glycolysis were heavily modified, including phosphoglycerate kinase 1 (PGK1), alpha-enolase (ENO1), pyruvate kinase isoform M2 (PKM2), ...
of regulatory RNAs. Numerous regulatory RNAs undergo mRNA-like RNA processing steps, such as 5′ m7G cap addition, polyadenylation, and splicing, which are observed even in long RNAs. The pattern of overlapping transcripts in the genome indicates the inclusion or exclusion of exons and introns in...