well-supported examples of variants in regulatory elements of genes involved in drug response, such as drug metabolizing enzymes and transporters (see review by Georgitsiet al. [1]), show that variants in noncoding regulatory sequences are also likely to be important ...
well-supported examples of variants in regulatory elements of genes involved in drug response, such as drug metabolizing enzymes and transporters (see review by Georgitsiet al. [1]), show that variants in noncoding regulatory sequences are also likely to be important ...
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space than the human genome using massively parallel...
SEQ ID:2 contains regulatory elements for expression of genes in eukaryotic cells. A plant expression vector is provided that comprises the regulatory element of SEQ ID:2 operably linked to a non-natively associated gene. This vector is used to produce transgenic plants.LYZNIK, LESZEK A...
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space th
Gene expression changes, the driving forces for cellular diversity in multicellular organisms, are regulated by a diverse set of gene regulatory elements that direct transcription in specific cells. Mutations in these elements, ranging from chromosomal aberrations to single-nucleotide polymorphisms, are a...
The Spec1 and Spec2 genes of Strongylocentrotus purpuratus are closely associated with the differentiation of aboral ectoderm. To examine cis-regulatory elements involved in the spatial expression of the Spec genes, we fused the Escherichia coli lacZ gene containing a nuclear targeting signal to 5′...
Transcription factors (TFs) andcis-regulatory elements (CREs) drive organism development. Suboptimal binding of TFs to CREs is shown to be key for the specificity of gene expression. New work now indicates that a similar principle governs the activities of TFs and their regulatory specificity. ...
A Genome-Wide Analysis of Open Chromatin in Human Epididymis Epithelial Cells Reveals Candidate Regulatory Elements for Genes Coordinating Epididymal Function The epithelium lining the epididymis has a pivotal role in ensuring a luminal environment that can support normal sperm maturation. Many of the ind...
建议阅读 Tags Organization Of Genes Genetic Material Cell's Nucleus Human Genes Non-coding DNA Promoter RNA Polymerase Transcription Initiation Site RNA Synthesis Transcription Termination Sequence Introns Exons Coding Regions Non-coding Material Silencers Repressors Gene Expression Protein Expression JoVE...