调节性T细胞(Regulatory cells,简称Tregs)是一类控制体内自身免疫反应性的T细胞亚群,早期亦称做Suppressor T cells。Tregs可分为天然产生的自然调节性T细胞(nTregs)和诱导产生的适应性调节性T细胞(aTregs或iTregs),如Th3、Tr1,另外还有CD8 Treg、NKT细胞等,与免...
Local administration of regulatory T cells promotes tissue healing Regulatory T cells (Tregs) are known for suppressing inflammatory processes, but their full capacity for tissue regeneration is yet to be harnessed. Here, the authors demonstrate the efficiency of Tregs in facilitating tissue healing in...
Tregs also express several immune checkpoint molecules including CTLA‐4, PD‐1, Tim‐3, LAG‐3, and TIGIT which deliver positive or negative immune modulatory signals on engagement with their cognate ligands expressed on antigen presenting...
Cellular therapy employing Foxp3-expressing regulatory T cells (Tregs) holds the promise to replace and/or supplement indiscriminatory immunosuppression by drugs. In order to achieve this goal in the clinic we need to learn more about the generation, lifestyle, and function of Tregs. One way to...
Regulatory T-cells (Tregs) are a type of white blood cell that suppresses the body’s immune response and prevents unnecessary inflammation. Tregs are part of the immune system and can enter the brain and the spinal cord to reduce neuroinflammation....
Suppressive capacity of expanded Tregs Figure 2. Presence of CD4± CD25+ cells during the three step isolation process.A.In the PBMC sample, 2.5% of the cells were CD4+CD25+.B.After negative isolation of CD4+ cells, 7% of the CD4+ cells expre...
Regulatory T cells (Tregs) are lymphocytes that control the biological phenomenon of self-non-self-discrimination. OriGene gives you a pre-selected antibody panel for Treg marker identification.
Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease. Cytotherapy 17, 473–486 (2015). CAS PubMed Google Scholar Di Ianni, M. et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117, 3921–...
调节性T细胞(Tregs),曾被称为抑制性T细胞,是T细胞的亚群,可调节免疫系统、维持对自身抗原的耐受、抑制自身免疫疾病。Tregs具有免疫抑制性,可抑制或下调效应T细胞的诱导和增殖。调节性T细胞有多种类型,其中研究最深的的一类表达CD4、CD25和FOXP3(CD4+CD25+调节性T细胞)。免疫系统必须能区分自我和非我。当自我/非我无...
Regulatory T cells(Tregs) are a subset of CD4+T cells that produce anti-inflammatory cytokines, such as IL-10 and TGFβ, which function to limit the activation of other immune cells and thus prevent excessive activity of the immune system in response to microbes or to self-antigens[108–11...