Besides its primary role in DNA damage response (DDR), ATM has been implicated in redox-sensing and proteostasis4, mitochondrial homeostasis via mitophagy5, autophagy of peroxisomes6. Very recently, cytoplasmic ATM was shown to segregate with and regulate endocytosis of synaptic vesicles, as opposite...
Due to the importance of ROS as signaling molecules in the brain, the high metabolic rate, and a relatively low antioxidant capacity, the brain is assumed to be particularly susceptible to an imbalance in ROS levels [34]. Oxr1-depleted mice display progressive cerebellar ataxia, shortened lifesp...
(RNAi). RNAi is a method of post-transcriptional control of gene expression, in which the introduction of small, sequence-specific, double-stranded RNAs into cells leads to the degradation of mRNAs that have a complementary sequence. Minus end ...
The trans-synaptic bridge formed between specific presynaptic neurexin alternative splice isoforms and specific postsynaptic neuroligin alternative splice isoforms promotes excitatory and inhibitory synaptogenesis in vitro, controlling their balance. A “splice-insert signaling code” is exploited regulating mutual...
Under the assumption that circRNA function will be related to the known function of the host gene, we performed a pathway analysis to predict potential functions of circRNAs up-regulated at E60. This analysis shows a significant contribution to Wnt signaling and axon guidance and, to a lesser ex...
Dendritic spines are actin rich-protrusions on dendrites, where excitatory synaptic transmission takes place in the brain. Similar to growing axons, the formation of dendritic spines is regulated by interaction between cell polarity components and the cytoskeleton. aPKC and Par6 function via p190RhoGT...
We performed functional magnetic resonance imaging during performance of implicit and explicit versions of a task in which subjects were presented with morphs of fearful facial emotional expressions. Participants were abstaining, multiply detoxified (MDTx; n=12) or singly detoxified patients (SDTx; n...
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesion s
In both human and mice, NRXN1 is co-expressed with numerous synaptic and cell signaling genes, and known schizophrenia candidates. Cross-species co-expression and protein interaction network analyses identified glycogen synthase kinase 3 beta (GSK3B) as one of the most consistent and conserved ...
MiR-138, which is enriched in the brain, negatively regulates the size of dendritic spines16. MiR-9 and miR-124, two highly conserved miRNAs that are most abundantly expressed in the mammalian nervous system, both play critical roles in controlling neuron fate and synaptic morphology. miR-9 ...