Protein kinase Bα (PKBα/Akt-1) is a key mediator of multiple signaling pathways involved in angiogenesis, cell proliferation and apoptosis among others. The unphosphorylated form of Akt-1 is virtually inactive and its full activation requires two phosphatidylinositol-3,4,5-triphosphate-dependent ...
MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling A previously unappreciated deubiquitinase activity of MCP-induced protein 1 contributes to its role in dampening inflammatory signaling. The intensity and ... J Liang,Y Saad,T Lei,... - 《Journal...
Deregulation of protein kinase B (Akt) signaling plays a vital role in the regulation of tumorigenesis in human cancers.192 K63-linked ubiquitination of Akt is required for Akt membrane translocation and activation.193 E3 ligase S-phase kinase-associated protein 2 (Skp2) overexpression is correlate...
in this review we discuss (1) the mechanistic regulation of MiTF/TFE transcription factors; (2) their roles in different regions of the central nervous system, in different cell types, and their involvement in the development of neurodegenerative diseases, including lysosomal storage disorders; (...
M22 could affect numerous cellular signaling processes such as apoptosis induction and growth inhibition of tumor cells. These effects included activation of NF-kappa B signaling as well as the protein kinases C (PKCα) and B (Akt), ornithine decarboxylase (ODC), phosphatidylinositol-3-kinase (...
B1 and B2 B cells differ in their ability to respond to T-cell-independent (TI) antigens. Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and critical role in the initiation of B1 but not B2 cell antigen receptor signaling. CD148 loss-of-function mice wer...
domain (vWC), a thrombospondin type 1 repeat (TSP1) and a C-terminal cysteine-knot (CK) domain. CCN5, previously denominated Wnt-inducible signaling pathway protein 2 (WISP2), is remarkable in the sense that it lacks the C-terminal cystine knot domain and confers actions opposite of the ...
The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Methods We charac...
signaling (p38 mitogen-activated protein kinase, MAPK) pathway also implicates theRunx2gene to control the mesenchymal precursor cell (MPC) differentiation.1The coordinated activity of Runx2 and BMP-activated Smads is critical for bone formation. Furthermore, a large number of gene products and ...
Knowing that the TP receptor signaling cascade involves the activation of Gαq and the stimulation of the downstream effector PLC-β, we investigated the effect of EBP50 on the signaling of the agonist-stimulated TP receptor through the Gαq pathway. Surprisingly, our experiments revealed that ...