Cell Adhesion Molecules组织白细胞细胞粘着分子Surgical wounds within previously irradiated tissues are subject to an increased incidence of postoperative complications including microvascular occlusion and impaired wound healing. The high radiation sensitivity of the vasculature has previously mainly been linked ...
(cSMAC and pSMAC). During T-cell activation, TCRs accumulate into a central cluster (known as the cSMAC) at the interface between the T cell and the APC. The cSMAC is surrounded by a leukocyte-function-associated antigen-1 (LFA1)-integrin ring (known as the pSMAC) in a bulls-eye...
We recently identified a resident neuroprotective lipid mediator pathway in the retina [6]. Metabolomic screening of homeostatic astrocytes identified lipoxins (LXA4and LXB4) as endogenous neuroprotective signals. The canonical role of lipoxins is the regulation of leukocyte and T-cell functions to ensu...
which fosters the selection of more aggressive, treatment-resistant cancer cells [74], and creates a physical barrier that shields tumor cells from immune cell attack and impedes the delivery of chemotherapeutic drugs, thereby
Analysis of isolated leukocyte subpopulations confirmed that monocytes mediate many of the transcriptional effects of social adversity, eg, of traumatic stress (O'Donovan et al, 2011), imminent bereavement, or chronic stress in caregivers of terminally ill patients (Miller et al, 2008, 2014). ...
Rap1a and Rap1b were shown to be essential for inside-out integrin activation and for integrin-dependent cell-matrix and cell-cell adhesion of various cell types, such as leukocytes, platelets, ovarial carcinoma cells, fibroblasts, and progenitor cells.10,11,14, 15, 16, 17, 18, 19, 20,...
Nevertheless, significant differences do occur in the action of individual chemokines, as the expression and secretion of each chemokine is sometimes separately regulated and depends on the cell type [26]. For this reason, to understand the interaction of all representatives of this gene cluster, ...
and endothelialization capacity of PEG-Au was measured in a rat model. After implanting the nanocomposites into rats subcutaneously for 4 weeks, PEG-Au 43.5 ppm was able to enhance the anti-immune response through inhibiting CD86 expression (M1 polarization), while also reducing leukocyte infiltration...
We recently identified a resident neuroprotective lipid mediator pathway in the retina [6]. Metabolomic screening of homeostatic astrocytes identified lipoxins (LXA4and LXB4) as endogenous neuroprotective signals. The canonical role of lipoxins is the regulation of leukocyte and T-cell functions to ensu...
Smith JR, Chipps TJ, Ilias H, Pan Y, Appukuttan B (2012) Expression and regulation of activated leukocyte cell adhesion molecule in human retinal vascular endothelial cells . Exp Eye Res 104 : 89–93Smith JR, Chipps T, Ilias H, Pan Y, Appukuttan B. Expression and regulation of ...