TGF-beta 1 is produced by every leukocyte lineage, including lymphocytes, macrophages, and dendritic cells, and its expression serves in both autocrine and paracrine modes to control the differentiation, proliferation, and state of activation of these immune cells. TGF-beta can modulate expression of...
Tumors form within the context of innate and adaptive immune responses and studies in skin and skin carcinogenesis models have provided important insight into the impact of context-dependent pro-inflammatory and immunosuppressive actions of TGFbeta1 on tumor development. Indeed, the paradigm of TGFbeta...
A crucial cytokine in the regulation of all aspects of an immune response is transforming growth factor beta (TGFβ). Although best known as a crucial regulator of T cell responses, TGFβ plays a vital role in regulating responses mediated by virtually every innate and adaptive immune cell, ...
autoantigen-specific inflammatory immune cells without compromising the immune responses to infectious pathogens and cancer. This finding has opened a way to develop similar immunotherapy for human autoimmune diseases. Furthermore, Dr. Chen discovered that D-mannose has a surprising therapeutic effects on...
The normal immune response is the outcome of interactions between antigens, immunologic cells, and microenvironments in the body. The challenges between the immune system and the antigens are under several different control mechanisms. These mechanisms w
According to current knowledge, the net outcome of T-cell immune responses seems to be significantly influenced by the activation stage of antigen-presenting DCs. Several studies have shown that transforming growth factor-beta 1 (TGF-β1) inhibits in vitro activation and maturation of DCs. TGF-...
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-beta. Genes Immun. 2014; 15: 511-520. Ref.: https://goo.gl/rRUDoJPalomares O, Martin-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar... O Palomares,M Martín-Fontecha,R Lauener,... - 《Gen...
The model also predicts coexistence of those phenotypes and Th1- or Th2-dominant immune responses in a spatial domain under various biochemical and bio-mechanical conditions in the microenvironment. 展开 关键词: Lipopolysaccharide Th17 TGF-Beta Mathematical model ...
Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such disea... Carsten,B,Schmidt-Weber,... - 《...
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