This IgM enhancement of the response to SRBC is highly reproducible and can furthermore be demonstrated in vitro. The time course and dose dependency of the response indicate that a critical antibody: antigen ratio is necessary for enhancement to occur. The IgM enhancement phenomenon has been ...
et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med. 4, 594–600 (1998). This is the first report of the ability of DC-derived extracellular vesicles that contain tumour antigens to stimulate an antitumour immune response...
Regulation of the immune response. V. Antibody-mediated inhibition of T and B cell cooperation in the in vitro response to red cell antigens The investigation of the mechanism by which antibody inhibits the production of antibody has been continued using the in vitro response of mouse spleen cel...
Recent findings indicate that increased metabolism of L-arginine by myeloid cells can result in the impairment of lymphocyte responses to antigen during immune responses and tumour growth. Two enzymes that compete for L-arginine as a substrate — arginase and nitric-oxide synthase — are crucial ...
As such, targeting these cells via direct ablation (e.g. enhanced ADCC, antibody drug conjugate, chimeric antigen receptor T cells CART), by reversal of their activated status (small molecule inhibitor targeting tyrosine kinase receptor), or by neutralising some of the factors they secrete could ...
OF THE DISSERTATION The Role of TCR Specificity in the Regulation of the Immune Response to Self and Commensal Antigens by Stephanie K. Lathrop Doctor of Philosophy in Biology and Biomedical Sciences: Immunology) Washington University in St. Louis, 2010 Dr. Chyi-Song Hsieh, Chairperson The immun...
Immunology The role of TCR specificity in the regulation of the immune response to self and commensal antigens WASHINGTON UNIVERSITY IN ST. LOUIS Chyi-Song Hsieh LathropStephanie KayOF THE DISSERTATION The Role of TCR Specificity in the Regulation of the Immune Response to Self and Commensal ...
Tolerance mechanisms should ensure that T and B cells are reactive enough to prevent infections, but not autoreactive, ie, do not stimulate the immune system in response to 'self' or 'auto' antigens. These mechanisms have been studied and the research has given rise to a number of ...
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular an
The primary anti-sheep red blood cells response and the response of antigen primed CBA mice aged 3–29 months were compared. There was a 30-fold decline with age in the primary immunological response, tested by the direct plaque-forming cell number. In young and young adult mice, priming re...