blood flow, but above the upper critical temperature the evaporative loss of heat becomes progressively more important until, when the average skin temperature equals the temperature of the environment, no further direct transfer is possible from the body and evaporation is then the sole remaining ...
Febrile temperatures boost the probability of an effective immune response by stimulating both the innate and the adaptive arms of the immune system. The pyrogenic cytokine interleukin-6 (IL-6) contributes to two phases of the febrile response: it elevates the core body temperature via thermoregulat...
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good reason; it fills the gap between two principal systems of the organism, the nervous system and the immune system. Although both systems affect each other through bidi
Bodytemperatureiscontrolledbybalancingheatproductionagainstheatloss.Autonomicthermoregulation Theregulatoryprocessofbodytemperatureperformedbyanintrinsicautonomicregulationmechanisminthebody.Behavioralthermoregulation:Humanbeingkeepsthebodytemperatureconstantthroughmanyconsciousactivities.
Currently, Gln is the only physiologically relevant substrate known to enhance the human heat shock response (24). However, the mechanism(s) by which Gln enhances Hsp expression remains elusive. Given the essential role of HSF1 in activating Hsp gene transcription and recent evidence indicating ...
Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, remain insuffici
The aqueous outflow pump fails in glaucoma due to the loss of trabecular tissue elastance, as well as alterations in ciliary body tension. These processes lead to SC wall apposition and loss of motion. Visible evidence of pump failure includes a lack of pulsatile aqueous discharge into aqueous ...
Adolescent depression is becoming one of the major public health concerns, because of its increased prevalence and risk of significant functional impairment and suicidality. Clinical depression commonly emerges in adolescence; therefore, the prevention a
The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a
The following publicly accessible datasets were also used: GSE107451 (scRNA-seq adult brain), GSE157202 (scRNA-seq larval brain), GSE101581 (scATAC-seq embryo). The neural network is from Özel et al5. Code availability The updated version of cisTopic for scATAC-seq clustering and topic ...