Cognitive function relies on a balanced interplay between excitatory and inhibitory neurons (INs), but the impact of estradiol on IN function is not fully understood. Here, we characterize the regulation of hippocampal INs by aromatase, the enzyme respon
Diameters of DNA-AuNPs conjugates in the open and closed states with different AuNPs:DNA ratios. Full size image Conclusions In summary, we developed a simple and reliable strategy for the reversible regulation of the catalytic activity of AuNPs, which was demonstrated with a glucose oxidation react...
has been challenged by the vision of Porter and van der Linde (1995a), who have moved from a static representation of firms’ profit maximization to a dynamic view of the impact of regulation on innovation and structural change. In this framework, environmental...
Accounts of self-regulatory failure suggest that self-regulation is subject to a limited strength model (Schmeichel & Baumeister, 2004). Accordingly, individuals have a “limited supply of willpower that is dedicated to acts of self-control”, with each “act of self-control draw[ing] from ...
The dynamic coordination of processes controlling the quality of the mitochondrial network is crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial proteolytic system, dynamics (fusion/fission), and mitophagy induce pathways that affect muscle mass and performance. ...
The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transition from acute kidney injury (AKI) to chronic
Summary SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug target will require structural knowledge and the design of selective small molecules. We have determined apo, and magnesium and ...
The prevalence of obesity is rapidly increasing worldwide, while the development of effective obesity therapies lags behind. Although new therapeutic targets to alleviate obesity are identified every day, and drug efficacy is improving, adverse side effe
Summary of the effects of sex steroids in aromatase and ERβ expression in XX and XY amygdala neurons. Differential expression of aromatase produces an imbalance in the E2:T ratio favouring E2 action in XY and T action in XX. In XY amygdala high levels of aromatase may favour E2 action (...
The overwhelming increase in the prevalence of overweight and obesity in recent years represents one of the greatest threats to the health of the developed world. Among current treatments, however, gastrointestinal (GI) surgery remains the only approach