It is becoming clear that alterations to metabolism balance the need of the cell for energy with its equally important need for macromolecular building blocks and maintenance of redox balance. To this end, a key molecule produced as a result of altered cancer metabolism is reduced nicotinamide ...
Semenza GL (2009) Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19(1): 12-16. doi:10.1016/j.semcancer.2008.11.009Semenza, G.L., 2009. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin. Cancer Biol. 19, 12-16....
Dysregulated cellular energetics are an emerging hallmark of cancer cells. The reprogramming of cellular metabolism is critical to maintain survival and limitless proliferation of cancer cells under severe conditions during development. Thus, disordered
Altered metabolism is a hallmark of cancer, but little is still known about its regulation. In this study, we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer cell-line (MCF7) across three different growth conditions. Integrating these multiomics data withi...
HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia Hypoxia-inducible factor 1 α (HIF1α) is an essential part of the HIF-1 transcriptional complex that regulates angiogenesis, cellular metabolism, and canc... H Geng,CT Harvey,J Pittsenbarger,... -...
2018, 12(4): 463–472 https://doi.org/10.1007/s11684-018-0668-2 REVIEW Regulation of T cell immunity by cellular metabolism ✉ ✉Zhilin Hu, Qiang Zou ( )a, Bing Su ( )b Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation...
Upregulation of enzymes associated with amino acid metabolism was found in breast cancer with high metastatic potentials. However, how altered amino acid metabolism modulates EMT development in breast cancer is unclear. Halldorsson et al. surveyed the metabolic profiling in the breast epithelial cell ...
Abstract Graphical abstract Keywords 1. Introduction 2. Physiological regulation and key structural features of the PMCA 3. The controversial role of PMCA in cell death 4. Metabolism, ATP supply and ATP dependency of PMCA 5. Summary ReferencesShow full outline Cited by (71) Figures (4)Cell...
After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation. As such, the metabolism of glutamine is intricately
Nature Metabolism volume 2, pages 1001–1012 (2020)Cite this article 23k Accesses 235 Citations 65 Altmetric Metrics details Abstract Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance. However, after prolonged...