13-P123 Regulation of BMP signaling pathway in Drosophila melanogasterPublication » 13-P123 Regulation of BMP signaling pathway in Drosophila melanogaster.doi:10.1016/j.mod.2009.06.596Enrica CharbonnierAlexander WeissMarkus AffolterGeorge Pyrowolakis...
nucleus.The signaling pathway can be regulated by many transcriptional co-activators and co-repressors at different molecular levels.In addition,other signaling pathways regulate BMPs signaling through "cross-talk".So BMP-Smads signaling regulation is not only a pathway but also a complex and ...
116,117 The most critical regulatory pathway of BMP signaling depends on the phosphorylation of Smad proteins.118,119,120,121 In addition, BMP signaling also interferes with multiple signaling pathways, including MAPK/PI3K/Akt, Wnt, hedgehog, and notch, and participates in the regulation of ...
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their behavior is regulated through a complex interplay of networks, including transcriptional, post-transcriptional, epigenet...
the other hand, non-canonical Smad-inde- pendent signaling (p38 mitogen-activated protein kinase, MAPK) pathway also implicates the Runx2 gene to control the mesenchymal precursor cell (MPC) differentiation.1 The coordinated activity of Runx2 and BMP-activated Smads is critical for bone formation....
Notch, epidermal growth factor (EGF), Wnt, and bone morphogenetic protein (BMP) signal transduction pathways are important regulators of ISC proliferation and differentiation in vertebrates and invertebrates (Spit et al., 2018). Recent studies uncovered roles for immune signaling in ISC survival, ...
Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells Wnt/β-catenin signaling pathway plays an important role in the genesis and development of Alzheimer's disease. The study aims to investigate the effect of... Xiong,...
These findings indicated that LIPUS stimulation enhanced osteogenic differentiation of hASCs possibly through the up-regulation of HSP70 and HSP90 expression and activation of BMP signaling pathway. Therefore, LIPUS might have the potential to promote the repair of bone defect. 展开 ...
One study demonstrated that high levels of typical BMP signaling were detected in hippocampal niches21. In addition, ligands of the BMP family are involved in the regulation of resting adult hippocampal stem cells and in the control of progenitor cell maturation at multiple stages of the neurogenic...
These results confirm the absolute requirement for adequate levels of CoA for proper neural and vascular development in zebrafish and point to the Bmp pathway as a possible molecular connection underlining the observed phenotype. 展开 DOI: 10.1038/srep37660 被引量: 9 ...