Yamaguchi H,Condeelis J.Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochimica et Biophysica Acta . 2007Yamaguchi H, Condeelis J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 2007;1773: 642-52....
MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Silencing of TMEM184B inhibited cancer cell migration and invasion, and regulated the actin cytoskeleton-pathway related genes.Loss of tumour-suppressive miR-....
The family proteins, () () and , are adaptor molecules that regulate cytoskeletal dynamics to promote multiple cellular processes, including migration, inv... MS Guerrero,JT Parsons,AH Bouton - 《Genes & Cancer》 被引量: 70发表: 2012年 Grb2 regulation of the actin-based cytoskeleton is requi...
Moreover, we discuss two important aspects of the actin cytoskeleton in controlling cancer: the engagement in multiple phases of immune cell activation and effector function as well as the role in cellular transformation. We conclude by reflecting on how these two aspects can be balanced in ...
Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with ageing and many diseases, including cardiological and neurodegenerative diseases, and cancer. Hence, maintaining the fine-tuned ...
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the arrangement of the actin cytoskeleton. By wound-healing assay, we have found that NIH 3T3 fibroblast cell...
Reorganization of the T-cell cytoskeleton is a rapid and dynamic process that is required to establish T-cell polarity and regulate cell–cell adhesion and T-cell activation. Actin polymerization leading to lamellipodium and distal-pole formation facilitates T-cell–antigen-presenting-cell (APC) rec...
TGF-β signaling in cell fate control and cancer - ScienceDirect Tight regulation of TGF-β superfamily signaling is important for normal cellular functions and tissue homeostasis. Since TGF-β superfamily ... Y Yu,XH Feng - 生物化学与生物物理学报:英文版 被引量: 13发表: 2018年 Modulating TGF...
Even a subtle decrease in PTEN levels and activity results in cancer susceptibility and favours tumour progression. Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existence of distinct PTEN isoforms and the ability of ...
12) (Fig. 6b,c), suggesting that ZO-1:claudin-18 complexes are tightly associated with the cytoskeleton22. Thus, we examined the effects of increased claudin-5 on the extractability of claudin-18, claudin-5 and ZO-1 by Triton X-100. Consistent with previous measurements, less than ∼35...