Yamaguchi H, Condeelis J (2007) Regulation of the actin cytoskel- eton in cancer cell migration and invasion. Biochim Biophys Acta 1773:642-652Yamaguchi, H., and J. Condeelis. 2007. Regulation of the actin cytoskeleton in can- cer cell migration and invasion. Biochim. Biophys. Acta. 1773...
MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Silencing of TMEM184B inhibited cancer cell migration and invasion, and regulated the actin cytoskeleton-pathway related genes.Loss of tumour-suppressive miR-....
Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with ageing and many diseases, including cardiological and neurodegenerative diseases, and cancer. Hence, maintaining the fine-tuned ...
Moreover, we discuss two important aspects of the actin cytoskeleton in controlling cancer: the engagement in multiple phases of immune cell activation and effector function as well as the role in cellular transformation. We conclude by reflecting on how these two aspects can be balanced in ...
Even a subtle decrease in PTEN levels and activity results in cancer susceptibility and favours tumour progression. Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existence of distinct PTEN isoforms and the ability of ...
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the arrangement of the actin cytoskeleton. By wound-healing assay, we have found that NIH 3T3 fibroblast cell...
cells. Therefore, targeting Rab GTPases to recover the dysregulated vesicle transport systems may provide potential strategy to restrain cancer progression. In this review, we discuss the regulation of Rab protein level and activity in modulating pathways involved in tumor progression, and propose that...
- 《Journal of Cancer Research & Clinical Oncology》 被引量: 31发表: 2007年 [Relation between changes of dendritic cell function and down-regulation of beta-centractin in hepatocellular carcinoma]. Objective To investigate the relation between the changes of dendritic cell(DC) function and down-...
Reorganization of the T-cell cytoskeleton is a rapid and dynamic process that is required to establish T-cell polarity and regulate cell–cell adhesion and T-cell activation. Actin polymerization leading to lamellipodium and distal-pole formation facilitates T-cell–antigen-presenting-cell (APC) rec...
Cofilins are key regulators of actin cytoskeleton dynamics and are well-known to undergo several different PTMs. Here, we show that cofilin-1 is conjugated by SUMO1 both in vitro and in vivo. Using mass spectrometry and biochemical and genetic approaches, we identify the N-terminal α-amino ...