DNA synthesis in MLR and cytotoxic activity in CML were not suppressed in cultures containing 3 1 2 day blastocyst outgrowths. The potent immunosuppressive properties of the trophoblast may be important during pregnancy by protecting the genetically dissimilar fetus from potentially harmful maternal ...
Adenovirus-infected PDC secreted IFN-α, β and ω in an 86:2:1 ratio. PDC type I interferons inhibited MDC differentiation and function (reduced IL-12 secretion, IFN-γ induction, MLR and CD40 expression, and increased CD1a+CD14+ cells). Type I interferon receptor blocking antibody reversed...
In 30 clinical AML samples, CD86 expression was significantly increased (P <.001) by SB treatment, and the expression of HLA-DR and ICAM-1 was moderately increased (P <.05) by SB treatment. Finally, the allogeneic mixed leukocyte reaction (allo-MLR) against HL60 cells pretreated with SB ...
T cell proliferative responses were determined by CFSE-MLR and cytokine production by cytokine bead array analysis. DAP12-/- mice were bred from pairs provided by Dr. Marco Colonna, Washington University School of Medicine. Wild-type (WT) C57BL/6 (B6) and TREM2-/- mice ...
Because C3 treatment did not affect the surface expression of HLA, costimulatory, and adhesion molecules of DC, we examined cytokine production of DC and naive CD4+ T cells to further elucidate the inhibitory mechanism of MLR. Unexpectedly, DC/C3 increased IL-12 production after LPS stimulation....
Indomethacin treatment (1 microgram/ml) of the RA auto-MLR led to increased production of supernatant inhibitory activity (8% +/- 4 without, 57% +/- 4 with indomethacin), but had no significant effect on the inhibition of EBV-induced B cell proliferation by normal auto-MLR supernatants. ...