These hormones significantly impact immune system function, suggesting that the connection between the immune system and circadian rhythm is not simply a direct regulation. In addition, the liver, as the metabolic hub of the human body, demonstrates distinct circadian rhythm patterns in glucose and ...
Immunohistochemistry was performed on free-floating brain slices (40 µm) using rabbit anti c-Fos primary antibody (Santa Cruz Biotechnology) as described previously [52]. Cells containing a nuclear brown-black 3,3′-diaminobenzidine (DAB) staining were considered as c-Fos positive cells. The...
NK cells are key components of innate immune systems and their activities are regulated by cytokines and hormones. All- trans retinoic acid (ATRA), as a me... A Li,M He,H Wang,... - 《Biochemical & Biophysical Research Communications》 被引量: 38发表: 2007年 加载更多来源...
Thus, more studies are required to decipher how sex differences affect microglial/macrophage activities, neuroinflammation, and neurofunctional outcomes after TBI. And more data are certainly warranted before any definite conclusion about the relationship among sex, sex hormones, and microglia/macrophages ...
Steroid hormones, immunosuppressants or their derivatives have been widely used to treat UC, but may cause severe adverse reactions, with a poor prognosis [10]. Therefore, it is necessary to find new alternative strategies to improve clinical outcomes and reduce adverse effects. The root of ...
Given the strong clinical evidence on COVID-19 disproportionately affecting men, the well-established role of peptidase in modulating ACE2 and SARS-Co-V-2 co-receptors, and the possible link between ACE2 expression and sex hormones, we sought to uncover the specific drug-protein interactions ...
Fibroblast growth factor 21 (FGF21) is secreted by hepatocytes as a peptide hormone to regulate glucose and lipid metabolism. FGF21 promotes hepatic ketogenesis and increases ketone body utilization in starvation. Histones are the target molecules of nut
Defense systems require considerable amounts of energy and resources, impairing plant growth, and plant hormones controlling transcriptional regulation play essential roles in establishing the appropriate balance between defense response to pathogens and growth. Chromatin regulators modulating gene transcription ...
As illustrated by our schematic model (Fig. 10), the current study reveals that hepatic IRE1a responds to catabolic cues (e.g., changes in hormones and metabolites) during extended periods of nutrient deprivation and modulates the mitochondrial b-oxidation and ketogenesis programs through the XBP1...
A Body weight changes during 20 weeks of the GAN diet. B Liver steatosis as shown in brightness during 20 weeks of the GAN diet. C Liver fibrosis as stiffness using Young’s Modulus during 20 weeks of the GAN diet (n = 6 WT and 7 Lyz-IFNγR2−/− mice). D Representative ...