Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure. However, how the remodeling activities of SWI/SNF complexes are regulated in eukaryotes rema...
Gene expressiontranscription factorssingle-moleculesuper-resolutioncell signalingintrinsically disordered proteinphase transitionmolecular crowdingfluorescent proteinHigh-speed single-molecule fluorescence microscopy in vivo shows that transcription factors in eukaryotes can act in oligomeric clusters mediated by ...
DNA encodes the genetic information in the cell, but in all eukaryotes, DNA is rarely found naked but usually packaged into a higher-order structure termed chromatin, which is composed of DNA and histones. The basic unit of the chromatin is the nucleosome, consisting of 147 base pairs of DNA...
Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer Circular RNA (circRNA) is a type of covalently closed non-coding RNA that may regulate gene expression in eukaryotes. The recent application of high-throug... C Bing,S Huang - 《Cancer Letters》 被引量: 7发表...
Furthermore, we show tractable scaling for higher-order eukaryotes with larger regulomes. Finally, we demonstrate that a Magma-predicted motif, which represents the binding specificity for HLH-30, plays a critical role in the host-defense to pathogenic infections. This novel finding shows that hlh...
Although introns are not directly involved in the translation of mRNA for protein synthesis, they play an important role in the regulation of gene expression [55]. In many cases, the presence of introns in eukaryotic gene coding regions can improve the gene expression. Introns are excised during...
In eukaryotes, transcription of protein-coding genes is performed by RNA Pol II.49, 50, 51 Genes transcribed by RNA Pol II typically require transcriptional regulatory elements (core promoters, proximal promoters, distal enhancers, and silencers) and the molecular machinery (general transcription factor...
YichengLong, 1 *XueyinWang, 1 *DanielT.Youmans, 1,2 *ThomasR.Cech 1† IthasrecentlybecomeapparentthatRNA,itselftheproductoftranscription,isamajorregulatorofthetranscriptional process.Inparticular,longnoncodingRNAs(lncRNAs),whicharesonumerousineukaryotes,functioninmanycasesas transcriptionalregulators.TheseR...
Background DNA demethylases regulate DNA methylation levels in eukaryotes. Arabidopsis encodes four DNA demethylases, DEMETER (DME), REPRESSOR OF SILENCING 1 (ROS1), DEMETER-LIKE 2 (DML2), and DML3. While DME is involved in maternal specific gene expression during seed development, the biologica...
To date, four delactylases have been reported9,10,11, while only p300 shows potential lactyltransferase activity in eukaryotes2. Global analysis proves that lysine lactylation is a widespread type of PTM in plant fungi12 and prokaryotes where there are not p300 homologs, suggesting that more ...