靶点(Target) c-RET 通路(Pathway) Protein Tyrosine Kinase CAS号(CAS NO.) 835621-07-3 分子式(Formula) C21H16Cl2F4N4O3 分子量(Molecular Weight) 519.28 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 运输和保存方法 -25~-15℃保存,有效期3年 ...
IC50 & Target:Raf-1 2.5 nM (IC50) Tie2 311 ± 46 nM (IC50) VEGFR2 4.2 nM (IC50) VEGFR1 13 nM (IC50) BRafV600E 19 nM (IC50) PDGFRβ 22 nM (IC50) Braf 28 nM (IC50) VEGFR3 46 nM (IC50) 热-销产品:Val-Cit-PAB-MMAE | Navitoclax | Acetylcysteine | Streptozotocin | Nusinersen...
它们仅供参考。 IC50 & Target:Raf-1 2.5 nM (IC50) Tie2 311 ± 46 nM (IC50) VEGFR2 4.2 nM (IC50) VEGFR1 13 nM (IC50) BRafV600E 19 nM (IC50) PDGFRβ 22 nM (IC50) Braf 28 nM (IC50) VEGFR3 46 nM (IC50) 热销产品:Cytochalasin D|Val-Cit-PAB-MMAE|Empagliflozin|Navitoclax|Cyclophosp...
Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. 溶解性:DMSO :90 mg/mL (186.4 mM) ...
西安齐岳生物科技有限公司生产销售“Regorafenib Intermediate,cas757251-39-1”“分子式:C13H12N3O2F , 分子量:261.25168,Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR??, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, re...
Regorafenib(Fig. 13) is an oral effective multi-target receptortyrosine kinaseinhibitor targeting VEGF, PDGFRs and Kit [67]. The IC50values of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR β, Kit, RET and Raf-1 are 13 nM, 4.2 nM, 46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM respectively.Regora...
2 reagents referenced in SHP-1 is a target of regorafenib in colorectal cancer.
Regorafenib is multikinase inhibitor with a target profile that partially overlaps with that of sorafenib, but is more potent.doi:10.1038/nrclinonc.2016.214David KillockSpringer NatureNature Reviews Clinical OncologyKillock D .Liver cancer : Rego rafenib - a new RESO RCE in HCC [J ] .Nat Rev...
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy. Regorafenib Chemical Structure CAS ...
Reproductive toxicity, Additional category for effects on or via lactation Specific target organ toxicity – repeated exposure, Category 1 Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1 Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1 ...