The brain tissues used in this study were obtained from the Joseph and Kathleen Bryan Brain Bank at Duke University, which has historical significance, as it contained brain samples that were instrumental in the discovery of the association between APOE-ε4 and late onset and sporadic Alzheimer's...
Chromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the