Applyingregionalpcsto Alzheimer's disease brain methylation data, combined with cell type deconvolution, we uncover 838 differentially methylated genes associated with neuritic plaque burden鈥攕ignificantly outperforming conventional methods. Integrating methylation quantitative trait loci with genome-wide ...
To quantify mucus composition, the stain vectors in the color deconvolution tool were applied to obtain separate images of the AB stained acidic mucins (blue) and PAS stained neutral mucins (purple/magenta). Subsequent procedures similar to the total subglandular area analysis were followed to ...
3.5. Cell types and risk variants linked with WM connectivity loss in PD low visual performers We investigated whether the most upweighted and downweighted genes associated with interhemispheric and subcortical-cortical connection loss were enriched in specific cell types. Cell-type expression profiles ...
Spatial transcriptomics, a novel technology to map the transcriptional architecture, is technically limited to discover T cell receptor (TCR) sequences as the 3' approach lacks sufficient coverage. Here, we established SPTCR-seq, a method to capture TCR sequences followed by long-read sequencing ...