HUCPVC and ECFC were pre-stained with Cell Tracker™ Green and Orange respectively for 20 min at 37 °C, 5% CO. Pre-stained cells were washed and resuspended in EGM. HUCPVC and ECFC cell suspensions were mixed at 1:2 (33k:66k) or 1:4 ratio (20k:80k) ratios for a total ...
at-SNE plot of 1173 single cells sequenced, generated from ESI-017 cells (n = 1, blue) or hES-derived chondrocytes digested from membranes at d40 of differentiation (n = 2 batches in red and orange).b, ct-SNE plots depicting expression of indicated genes at single cell resolutio...
regeneration121,122,123(see Table2for a summary of these phenotypes). Heart injury promotes Ctgfa secretion into the ECM from endocardial cells, where it promotes the expression of pro-regenerative ECM genes (such as fibronectins and collagens)121. This expression allows for a transient scar, ...
(d, e) To implement the 2 prepared sockets (yellow) designed in (Fig. 1 Ac), a red surgical guide was designed for the buccal yellow socket, and an orange surgical guide was designed for the palatal yellow socket. (f, g) For the buccal yellow socket designed in (Fig. 1 Ac) ((d...
Asterisks indicate annotations common to a and b, shown in blue or orange if reduced or increased in significance, respectively, following cell therapy (+CP versus –CP). c Venn diagram indicates enriched (Benjamini–Hochberg corrected p < 0.001) Gene Ontology (GO) Biological Processes ...
The extent of tissue regeneration varies widely between species. Mammals have a limited regenerative capacity whilst lower vertebrates such as the zebrafish (Danio rerio), a freshwater teleost, can robustly regenerate a range of tissues, including the sp
Sonic Hedgehog (Shh), secreted from gastric parietal cells, contributes to the regeneration of the epithelium. The recruitment of macrophages plays a central role in the regenerative process. The mechanism that regulates macrophage recruitment in respons
Double labeling, seen as a yellow/orange fluorescence, is observed by dual bypass filter microscopy (bottom row). Donor-derived cells within the infarct express the mature neuronal markers NeuN and neurofilament (NF) (donor-derived neurons indicated by arrowheads, non-neuronal engrafted cell ...
interactions of TGFβ signalling molecules (derived from the IPA knowledge base) allow the prediction of the downstream cellular effects of TGFβ modulation (c, d). The orange inflammatory designation indicates the activation of an inflammatory cellular response to the pro-inflammatory gene ...
4c right versus left, in pink, purple, orange, and green, respectively). This CP-induced environment had substantial reductions in metabolism and biosynthesis processes (Fig. 4c right versus left, yellow and blue circles, respectively) whereas new functions emerged. These included: protein ...