However, the reference-based imputation methods were not formally justified. We present a causal model which makes an explicit assumption in a potential outcomes framework about the maintained causal effect of treatment after discontinuation. We use mathematical argument and a simulation study to show ...
Carpenter et al (2013) proposed reference-based imputation methods which use a reference arm to inform the distribution of post-discontinuation outcomes and hence to inform an imputation model. However, the reference-based imputation methods were not formally justified. We present a causal model ...
Reference-based controlled imputations have become a popular tool to assess the sensitivity of primary analysis inference to different post-dropout assumptions and to yield an alternative effectiveness estimand of treatment effect. As the imputation and analysis models are uncongenial in this setting, ...
Reference Based Multiple Imputation (rbmi) Overviewrbmi is a R package for imputation of missing data in clinical trials with continuous multivariate normal longitudinal outcomes. It supports imputation under a missing at random (MAR) assumption, reference-based imputation methods, and delta ...
Reference‐based imputation has two advantages: (a) it avoids the user specifying numerous parameters describing the distribution of patients' postwithdrawal data and (b) it is, to a good approximation, information anchored, so that the proportion of information lost due to missing data under the...
if imputation = temp; rename treated=beta bsvalue=gamma; keep imputation lambda1-lambda&nint treated bsvalue; run; * merge with raw data; proc sql noprint; create table raw2 as select a.*, b.* from postsamp2 as a, raw1 as b ...
(2021). Rapid genotype imputation from sequence with reference panels. Nature Genetics. https://doi.org/10.1038/s41588-021-00877-0 廉价的基因分型方法对现代基因组学至关重要。作者开发了QUILT工具,对低覆盖率的全基因组测序数据执行二倍体基因型填充。通过利用吉布斯采样,QUILT首先将读段划分为母本集和...
To assess imputation based on the phase 3 data set, we used Complete Genomics data for 9 or 10 individuals from each of 6 populations (CEU, CHS, LWK, PEL, PJL, and YRI). After excluding these individuals from the reference panel, we imputed genotypes across the genome using sites on a...
The Absolute method refers to direct integration of data after preprocessing such as normalization, log2 transformation, missing value filtering and imputation. Ratio Ratio-based scaling refers to converting the quantitative profiles to relative-scale profiles within each batch on a feature-by-feature ba...
Current genome-wide association studies (GWAS) use commercial genotyping microarrays that can assay over a million single nucleotide polymorphisms (SNPs). The number of SNPs is further boosted by advanced statistical genotype-imputation algorithms and large SNP databases for reference human populations. Th...